Check out Neuromics' various categories of antibodies that target proteases. Including Presenilins, Kallikreins/KLKs, Matrix Metalloproteinases, and Capspaes and Cathepsins
- Presenilins
Presenilins are a family of related multi-pass transmembrane proteins that function as a part of the gamma-secretase protease complex. Presenilins undergo cleavage in an alpha helical region of one of the cytoplasmic loops to produce a larger N-terminal and a smaller C-terminal fragment which together form part of the functional protein. Cleavage of presenilin 1 can be prevented by a mutation which causes the loss of exon 9, and results in loss of function. Presenilins play a key role in the modulation of intracellular Ca2+ involved in presynaptic neurotransmitter release and long-term potentiation induction.
Dominant mutations in the genes that encode presenilin proteins are the most common cause of familial early-onset Alzheimer's disease.
Name Catalog # Type Species Applications Size Price Presenilin 1 RA18020 Rabbit IgG Human, Mouse, Rat, Primate WB, IP 100 ul $425.00 Presenilin 2 RA18004 Rabbit IgG Human, Mouse, Rat, Primate ICC, WB, IHC, IP 100 ul $425.00 - Kallikreins/KLKs
Kallikriens are serine proteinases. The human tissue kallikrein gene family contains 15 members that play important roles in cancer. KLK6 has been implicated in Parkison's and Alzheimer's and shown be elevated in animal models of multiple sclerosis. KLK8 has been shown to be elevated in the hippocampus on Alzheimer’s patients’ brains and animal models of autoimmune encephalomyelitis
Name Catalog # Type Species Applications Size Price Aurora A/B/C kinase MO22139 Mouse IgG Human, Mouse, Rat, Chicken, Bovine, Porcine, Equine ICC, WB, IHC, IF 100 ul $325.00 Aurora B kinase MO22138 Mouse IgG Human, Mouse, Rat, Chicken, Bovine, Porcine ICC, WB, IHC, IF 100 ul $325.00 Kallikrein 5/KLK5/KLKL2 RA19046 Rabbit IgG Human WB 100 ug $225.00 KLK-L1 RA19045 Rabbit IgG Human WB 100 ug $225.00 KLK-L3 (KLK9) RA19047 Rabbit IgG Human WB 100 ug $225.00 KLK-L4 RA19048 Rabbit IgG Human WB 100 ug $225.00 - Matrix Metalloproteinases
Matrix Metalloproteinases (MMPs) are a family of zinc metalloendopeptidases secreted by cells, and are responsible for much of the turnover of matrix components. They are produced as zymogens, with a signal sequence and propeptide segment that must be removed during activation. In general, This signal sequence and propeptide plus a catalytic domain (containing the highly conserved zinc binding site) characterizes the structure of the MMPs.
MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, uterine involution, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, malignant gliomas, lupus, arthritis, periodontis, glumerulonephritis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis.
Name Catalog # Type Species Applications Size Price ADAM15 RA21008 Rabbit IgG Human, Mouse, Rat ICC, WB, IHC, IF 50 ug $380.00 CKB GT34002 Goat IgG Human, Mouse, Rat, Bovine, Dog WB, E 100 ug $499.00 MMP1 (Matrix Mellatopeptidase 1), N terminal region RA21020 Rabbit IgG Mouse ICC, WB, IHC, IF 100 ug $492.00 MMP2 (Matrix Mellatopeptidase 2), C terminal region RA21021 Rabbit IgG Human ICC, WB, IHC, IF 100 ug $492.00 MMP9 (Matrix Mellatopeptidase 9), N terminal region RA21022 Rabbit IgG Human, Mouse, Rat ICC, WB, IHC, IF 100 ug $492.00 - Caspases and Cathepsins
Caspases and Cathepsins are proteases involved in apoptosis. They also are implicated in cancer and other research areas.
Name Catalog # Type Species Applications Size Price CARD8 RA30062 Rabbit IgG Human WB, IHC 50 ug $435.00 CARD9 RA30063 Rabbit IgG Human WB, IHC 50 ug $435.00 Caspase-14 RA30061 Rabbit IgG Human WB, IHC 50 ug $555.00 Caspase-3 (C terminal region) RA21011 Rabbit IgG Human ICC, WB, IHC, IF 50 ug $379.50 Caspase-3 (N terminal region) RA21012 Rabbit IgG Human ICC, WB, IHC, IF 100 ug $313.50 Caspase-7 MO25036 Mouse IgG Human, Mouse, Rat WB 100 ul $379.00