Product Details
Catalog Number: RA30063
Applications: WB, IHC
Type: Rabbit IgG
Immunogen: KLH-conjugated synthetic peptide (DRENTTGSDNTDTEGS) corresponding to to amino acids 521 to 536 of human CARD9.
Storage: Store at 4°C. Do not freeze.
Shipping: Refrigerated (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human
Entrez: 64170
UniProt: Q9H257
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
50 ug$435.00Add to Cart

CARD9 interacts with the CARD activation domain of BCL-10. CARD9 associates with BCL-10 and forms a complex within cells. CARD9 induces apoptosis and activates NF-kB. CARD9 is an upstream activator of BCL-10 and NF-kB signaling.

Defects in CARD9 are the cause of familial candidiasis type 2 (CANDF2) [MIM:212050]. Chronic mucocutaneous candidiasis is characterized by impaired clearance of fungal infections and results in colonization and infections of the mucosa or skin, predominantly with Candida albicans. CANDF2 is an autosomal recessive chronic mucocutaneous candidiasis.

Images

Human Adrenal tissue (formalin-fixed, paraffin-embedded) stained with CARD9 antibody at 5.0 ug/ml followed by Goat anti-rabbit IgG, Biotin-Catalog#:GT30001, alkaline phosphatase-streptavidin and chromogen.

Human Adrenal tissue (formalin-fixed, paraffin-embedded) stained with CARD9 antibody at 5.0 ug/ml followed by Goat anti-rabbit IgG, Biotin-Catalog#:GT30001, alkaline phosphatase-streptavidin and chromogen.

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