At Neuromics, we strive to provide reagents that customers can trust. One of the ways we build trust is by highlighting published research using our products, showing that our reagents truly walk the talk.
Earlier this month, researchers from the Medical College of Wisconsin and the Mississippi University Medical Center published their findings on the role of Piezo2 using human Schwann Cells (cat.# HMP303) from Neuromics.
Image: IHC delineation of Piezo2 (PZ2) axonal component and Schwann cell expression. In image I, Neuromics human Schwann Cells show double immunostaining of Piezo2 (red) and S100 (green). Scale bar: 50 µm for all.
Read more to learn about their findings...
Piezo2 has been understood as a key mediator of sensory neurons for sensing and transducing touch and vibrations. In this paper, researchers wondered whether the function of Piezo2 extends beyond touch. Checking for Piezo2 expression in various cell types, including Neuromics human Schwann Cells, they found that the function of Piezo2 likely extends beyond touch. Based on the profile of immunoreactivity, they hypothesize that Piezo2 may play a role in sensory processes in the spinal cord, Schwann cells, and skin melanocytes, along with pain pathogenesis.
Citation:
- Seung Min Shin, Francie Moehring, Brandon Itson-Zoske, Fan Fan, Cheryl L. Stucky, Quinn H. Hogan, and Hongwei Yu. (2021). Piezo2 Mechanosensitive Ion Channel is Located to Sensory Neurons and Non-Neuronal Cells in Rat Peripheral Sensory Pathway: Implications in Pain.bioRxiv. doi: 10.1101/2021.01.20.427483