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| Size | List Price | Price | Cart |
|---|---|---|---|
| 100 ul | $425.00 | Add to Cart |
Presenilin-1 (PS-1) and Presenilin-2 (PS-2) are integral membrane proteins that contain multiple transmembrane domains. Both are predominantly located within the endoplasmic reticulum (ER) and early Golgi apparatus. They are primarily expressed in neurons and are ubiquitously expressed in the brain. PS-1 and PS-2 are proteolytically cleaved to generate an N-terminal fragment (NTF) and a C-terminal fragment (CTF). Mutations in the gene for Presenilin may play an important role in the pathology of Alzheimer's disease. |
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Name Catalog # Size Presenilin 1 RA18020 100 ul
Images
Presenilin 2 staining in paraffin-embedded human brain, showing both nuclear and cytoplasmic protein localization. Data courtesy of Cell Signaling Technology, Inc.
Presenilin 2 staining in paraffin-embedded human brain, showing both nuclear and cytoplasmic protein localization. Data courtesy of Cell Signaling Technology, Inc.