Product Details
Product Sizes
| Size | List Price | Price | Cart |
|---|---|---|---|
| 100 ul | $425.00 | Add to Cart |
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2). Presenilins form the catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Evidence suggests cleavage of APP by gamma-secretase and the production of Abeta (42 aa) is likely to play a important or casual role in the development of Alzheimer's disease. |
- Product Reviews- - Rating:
Leave a review for this product and you could be eligible for a $10 Starbucks gift card.
- Product Publications
Product Publications
If you've used this product in a publication, let us know. Email pshuster@neuromics.com, with the publication details and you could be eligible for an Amazon gift card.
- Related Products
Related Products
Name Catalog # Size Presenilin 2 RA18004 100 ul
Images
Presenilin 1 Antibody detects endogenous levels of the carboxy-terminal fragment of presenilin 1 (~22 kDa). The antibody detects the full length protein (55k Da) to a lesser extent. Western blot image shows extracts from HeLa (1), SK-N-MC (2) and COS (3) cells probed with Presenilin 1 antibody.
Presenilin 1 Antibody detects endogenous levels of the carboxy-terminal fragment of presenilin 1 (~22 kDa). The antibody detects the full length protein (55k Da) to a lesser extent. Western blot image shows extracts from HeLa (1), SK-N-MC (2) and COS (3) cells probed with Presenilin 1 antibody.