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As IBA Lifesciences US distributor, Neuromics offers our customers cutting-edge protein purification products. IBA is constantly introducing resins with greater capacity and higher yields. Strep-Tactin® 4Flow® High Capacity is now available as a new and improved version of our top-selling protein purification product.

The new resin consists of a low concentrated (4%) and pressure stable agarose coupled with high Strep-Tactin® density. These specifications lead to:

• High protein binding capacity
• Applicability for FPLC workstations
• High yields for all protein classes, especially large proteins
• Superior stability enabling at least 50 regeneration cycles

Earlier this year, Neuromics released our first set of iPSC-derived brain cells. In our blog post at the time, we suggested that more iPSC-derived cells would be released. That day is upon us, as we've just released another six iPSC-derived cell types.

• Human iPSC - Dopaminergic Neurons (cat. IPS004)
• Human iPSC - Cortical GABAergic Neurons (cat. IPS005)
• Human iPSC - Sensory Neurons (cat. IPS006)
• Human iPSC - GFP Glutamatergic Neurons (cat. IPS007)
• Human iPSC - ALS Neural Stem Cells (cat. IPS008)
• Human iPSC - Neural Stem Cells (cat. IPS009)

We're not stopping here either, as more cells will be released in the coming weeks.

Image: Neuromics Human iPSC Cortical GABAergic Neurons (cat. IPS005) in culture.

All are derived from integration-free iPSC lines under a fully defined proprietary neural induction condition. The source of the cells are primary fibroblasts obtained from healthy donors.

At the front and center of our human cell & tissue offerings are our primary brain & CNS cell types. Over the years, these cells have contributed to impactful studies. Earlier this week, another publication was released reminding us again of their value to researchers.

Investigators at the University of Nottingham used our Human Brain Pericytes (cat. HMP104), Astrocytes (cat. HMP202), and Microvascular Endothelial Cells (HBMECs) (cat. HEC02) to study the effects of hyperglycemia on the blood-brain barrier (BBB). The scientists built an in vitro BBB model by co-culturing the three cell types.

Image: Neuromics HBMECs showing tubule formation in normoglycemic conditions. The investigators found that the angiogenic capacity and morphology of the HBMECs were not altered by various glucose levels.

They found disruptions to the integrity of the BBB after exposure to high glucose conditions after 48 and 72 hours as compared to the normoglycemia control. The findings have implications for furthering our understanding of the link between diabetes and strokes. You can read the full study here.

Our Human Retinal Microvascular Endothelial Cells (HRMECs) (cat. HEC09) have a history of performing for researchers studying diabetic retinopathy. In the past, we've seen the cells used to investigate the viability of a drug as a treatment in one study and the role of a long non-coding RNA in another paper. Now, the cells are back again, proving their consistency and reliability in a publication released this month.

Image: Formation of tube networks in Neuromics HRMECs in normal glucose (NG) and high glucose (HG) conditions.

Investigators at Shandong University in China subjected our HRMECs to high glucose (HG) conditions to create an in vitro diabetic retinopathy model. They wanted to study the role of circular RNAs (circRNAs) in regulating HG-induced apoptosis in the HRMECs. Finding that hsa_circ_0000880 was upregulated in the cells and that apoptosis decreased in the hsa_circ_0000880 knockout model, the researchers suggest it could be a future therapeutic target for diabetic retinopathy. You can read the full study here.

Are you planning any cell culturing projects this Spring? Now is the time to save big on our Preferred Fetal Bovine Serum (FBS) (cat. FBS007). Neuromics Preferred FBS is the best bang for your buck and is now only $250/500 ml through the end of May.

Like all our FBS products, Preferred FBS is manufactured in a fully integrated environment from raw material collection to finished product. It is triple 0.1 μm filtered and free of viruses and mycoplasma. A heat inactivated version (cat. FBS007-HI) is also available and on sale ($255/500 ml).

Preferred FBS offers a level of quality to grow most cell types while being available at the lowest price. We encourage all of our FBS customers to give it a shot. However, if you are working with more sensitive cell types or need specialty FBS for your application, we always have further options available. Check out an explanation of all our FBS products here.