Last week, we shared some exciting new research using our immortalized CAFs. It didn't take long for us to come across another publication with some noteworthy findings. Researchers at Augusta University published a study earlier this year utilizing our 3D Human Blood-Brain Barrier (BBB) Model (cat. 3D45002) in Alzheimer’s Disease (AD) research.
In recent years, periodontitis (PD) has been linked to AD, however, the mechanism is not understood. Porphyromonas gingivalis (Pg), a bacteria that causes PD, has been found in post-mortem brain samples of AD patients. The investigators tested to see whether PD-induced exosomes can cross the BBB.
Image: TEER readings in Neuromics BBB model at different time points when blood side is exposed to PD exosomes (PD EXO) and health exosomes (Con EXO). Exposure to PD EXO decreases TEER readings.
With the help of our model, the scientists found that not only do PD-induced exosomes cross the BBB, but they also compromise its integrity. TEER readings and expression of tight-junction proteins both decrease after exposure to the exosomes. These findings give some insight into how PD may contribute to the development of AD. Read the full study here.
Our 3D BBB Model mimics the BBB in vivo. Layered in an insert, human brain endothelial cells form the blood side, while co-cultured brain pericytes and astrocytes comprise the brain side. We have 6 well, 12 well, and 24 well versions available. We also offer services where we can test whether your articles of interest cross the BBB. Contact us for more details.
Like with all of our human cells, our BBB model is currently 15% off until the end of the month. Learn more here.