Product Details
Product Sizes
| Size | List Price | Price | Cart |
|---|---|---|---|
| 100 ug | $365.00 | Add to Cart |
TRIM RING finger protein TRIM2, a ubiquitin ligase, is highly expressed in the nervous system. It binds to neurofilament light subunit (NF-L);and regulates NF-L ubiquitination. Deficiencies in TRIM2 increases NF-L level in axons and NF-L-filled axonal swellings in cerebellum, retina, spinal cord, and cerebral cortex. These deficiencies eventually lead to neurodegeneration, tremors and ataxia. It is proposed that TRIM2 has neuroprotection properties. |
Images
TRIM2 (dilution: 6.3 µg/ml) staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Note cytoplasm staining in neuronal cell bodies. Protocol on datasheet.
TRIM2 (dilution: 0.5 µg/ml) staining of Rat Brain lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.