Product Details
Product Sizes
| Size | List Price | Price | Cart |
|---|---|---|---|
| 100 ug | $365.00 | Add to Cart |
Human glutamate receptor 4 (GRIA4) is a new member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. Binding studies showed that human GluR4 transfected into simian kidney cells (COS-1) exhibits high specific binding for[3H](RS)-alpha-amino- 3-hydroxy-5-methylisoxazole-4-propionic acid ([3H]AMPA) but not [3H]kainate. Ion substitution experiments indicate that hGluR4 receptor-linked ion channels in their homomeric state are permeable to both CA2+ and Na+ ions. Immunoprecipitation studies suggest that GRIA1 exists in situ in the form of a pentamer. Nociceptors, involved primarily in the mediation of neuropathic pain, may be presynaptically modulated by GluR4-containing AMPA receptors. |
Supporting Products
| Name | Catalog # | Size |
|---|---|---|
| GABA A receptor alpha 4 | P41012 | 100 ug Blocking Peptide |
Images
GluR4 (0.3µg/ml) staining of Human Cerebellum lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
GluR4 staining of human brain tissue, cortex (formalin-fixed paraffin-embedded) at 5 ug/ml followed by biotinylated horse anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Protocol on data-sheet.