Product Details
Product Sizes
| Size | List Price | Price | Cart |
|---|---|---|---|
| 50 ul | $205.00 | Add to Cart |
Met-enkephalin (tyr-gly-gly-phe-met) and leu-enkephalin (tyr-gly-gly-phe-leu) are pentapeptides which compete with and mimic the effects of opiate drugs. Although interest in enkephalins stems largely from their possible role in the brain, the richest source of these peptides is the adrenal gland. The amino acid sequence shows that the precursor is 267 amino acids long and contains 6 interspersed Met-enkephalin sequences and 1 Leu-enkephalin sequence. The precursor does not contain the sequences of dynorphin, alpha-neo-endorphin or beta-endorphin. (Because of structural similarities it had been postulated that beta-endorphin is precursor of Met-enkephalin, and that dynorphin or alpha-neo-endorphin is precursor of Leu-enkephalin.) It is involved in the modulation of nociceptive pain. ppENK may be capable of enhancing immune function in cancer or AIDS patients. |
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- Product Publications
Product Publications
- Ryohei Tomioka, Naoki Shigematsu, Toshio Miyashita, Yukie Takahashi, Mariko Yamamoto, Yumiko Yoshimura, Kenta Kobayashi, Yuchio Yanagawa, Nobuaki Tamamaki, Takaichi Fukuda and Wen-Jie Song. (2024). The External Globus Pallidus as the Hub of the Auditory Cortico-Basal Ganglia Loop. eNeuro, 11(11). doi: 10.1523/ENEURO.0161-24.2024
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Images
Immunohistochemistry analysis of mouse brain striatum transfected with ppENK (RA14142). Neurons and synaptic vesicles are stained in the image.
Immunohistochemistry analysis of mouse brain striatum transfected with ppENK (RA14142). Neurons and synaptic vesicles are stained in the image.