Product Details
Catalog Number: RA30052
Applications: WB, IHC
Type: Rabbit IgG
Immunogen: KLH conjugated synthetic peptide-15 amino acid sequence from the middle region of human RHEB.
Storage: Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat
Entrez: 6009
UniProt: Q15382
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
50 ug$435.00Add to Cart

RHEB (Ras homolog Enriched in Brain) is an evolutionarily conserved member of the Ras family of small GTP binding proteins originally found to be rapidly induced by synaptic activity in the hippocampus following seizure.  It also involved in synaptic plasticity.

RHEB triggers activation of the Raf-MEK-MAPK pathway. Biochemical and genetic studies demonstrate that it has an important role in regulating the insulin/Target of rapamycin (TOR) signaling. This pathway could initiate the growth of pancreatic beta cells making RHEB a potential target for diabetes therapies.

Images

RHEB staining of Human Cortex (formalin-fixed, paraffin-embedded) at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

RHEB staining of Human Cortex (formalin-fixed, paraffin-embedded) at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

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