Product Details
Currently out of stock - contact david@neuromics.com for more information Musashi1, a neural RNA-binding protein, plays an important role in regulating cell differentiation in precursor cells. Musashi-1 (Msi-1) has been shown to increase the accumulation of tau isoforms in intracellular inclusions in dementia and Parkinson's. The presence of Msi-1 in a significant percentage of neurons containing cytoplasmic inclusions in 2 other neurodegenerative diseases Alzheimer's disease and Pick disease suggests that it may play a role in the pathogenesis of these neurodegenerative disorders. Musashi1 has also been detected in human tumor tissues such as gliomas and melanomas, suggesting its involvement in cancer development. Msi-1 also appears to play be an vital role in the development of several types of carcinoma such as human hepatoma, and may be a useful molecular marker for tumor detection. |
- Product Reviews- - Rating:
Leave a review for this product and you could be eligible for a $10 Starbucks gift card.
- Product Publications
Product Publications
- Seung Ah Choi, Eun Jung Koh, Ryong Nam Kim, Jung Woo Byun, Ji Hoon Phi, Jeyul Yang, Kyu-Chang Wang, Ae Kyung Park, Do Won Hwang, Ji Yeoun Lee, and Seung-Ki Kim. (2020). Extracellular Vesicle-Associated miR-135b and -135a Regulate Stemness in Group 4 Medulloblastoma Cells by Targeting Angiomotin-Like 2. Cancer Cell International, 20, 558. doi: 10.1186/s12935-020-01645-6
- Amanda K. Silva, Hyun Yi, Sarah H. Hayes, Gail M. Seigel, Abigail S. Hackam. (2010). Lithium chloride regulates the proliferation of stem-like cells in retinoblastoma cell lines: a potential role for the canonical Wnt signaling pathway. Molecular Vision 2010; 16:36-45.
- Min-Tsai Liu, Yung-Hui Kuan, Jingwen Wang, René Hen, and Michael D. Gershon. (2009). 5-HT4 Receptor-Mediated Neuroprotection and Neurogenesis in the Enteric Nervous System of Adult Mice. The Journal of Neuroscience, August 5, 2009, 29(31):9683-9699; doi: 10.1523/JNEUROSCI.1145-09.2009
- Sujoy K. Dhara, Kowser Hasneen, David W. Machacek, Nolan L. Boyd, Raj R. Rao, Steven L. Stice. (2008). Human neural progenitor cells derived from embryonic stem cells in feeder-free cultures. Differentiation, 76 (5), 454–464. doi: 10.1111/j.1432-0436.2007.00256.x
If you've used this product in a publication, let us know. Email pshuster@neuromics.com, with the publication details and you could be eligible for an Amazon gift card.
- Related Products
Related Products
Name Catalog # Size α-Internexin/NF 66 MO22102 100ul α-Internexin/NF 66 MO22154 100 ul AP-2 Alpha RA18023 100 ul ATPase Na+/K+ transporting alpha 1 MO25023 50 ul Doublecortin/DCX MO22113 100 ul GAP43 CH22132 100 ul GAP43 MO22118 100 ul GAP43 MO22170 100 µl GAP43 RA25086 100 ul GAP43 (IgG) MO22171 100 µl Laminin RA25038 100 ul Laminin 111 RA22121 100 ul MSX1/HOX7 GT41015 100 ug Nestin CH22123 100 ul Nestin MO22183 100 ug Nestin RA22125 100 ul Netrin-4 (NTN4) RA21023 50 ug Neurofilament alpha-internexin/NF66 CH22101 100 ul Neurofilament alpha-internexin/NF66 MO25017 500 ul Neurofilament alpha-internexin/NF66 RA22102 100 ul Notch3 RA19070 100 ug PAX-8 MO47029 100 ul PAX3 GT41025 100 ug Podoplanin MO47016 100 ul S-100 MO47059 100 ul SOX-2/SRY (sex determining region Y)-box 2 MO47038 100 ul SOX2 RA25021 100 ul SRY (Sex Determining Region Y)-Box 11/SOX-11 MO47052 100 ul Vimentin CH22108 100 ul Vimentin GT22103 100 ul Vimentin MO22115 100 ul Vimentin RA22124 100 ul
Images
Musashi (green) staining of neural rosettes(human). Nuclei are counterstained blue (DAPI). Image courtesy of Drs. Patricia Wilson and Steve Stice, University of Georgia.
Musashi (green) staining of neural rosettes(human). Nuclei are counterstained blue (DAPI). Image courtesy of Drs. Patricia Wilson and Steve Stice, University of Georgia.
Musashi-positive cells in the ventricular zone of E14.5 mouse medulla. Picture was taken at 200x magnification. The sections are 4% PFA fixed, paraffin-embedded and cut at 5 micron. Courtesy of Xi Huang, Chiang Lab, VUMC.
Musashi-positive cells in the ventricular zone of E14.5 mouse medulla. Picture was taken at 200x magnification. The sections are 4% PFA fixed, paraffin-embedded and cut at 5 micron. Courtesy of Xi Huang, Chiang Lab, VUMC.
RB116 cells stained with Musashi-1 at 15 μg/ml
RB116 cells stained with Musashi-1 at 15 μg/ml
Immunostaining of hNP1 Progenitors before and after differentiation. The culture was highly homogenous with neural rosettes. DOI: 10.1111/j.1432-0436.2007.00256.x.
Immunostaining of hNP1 Progenitors before and after differentiation. The culture was highly homogenous with neural rosettes. DOI: 10.1111/j.1432-0436.2007.00256.x.