Product Details
This product is no longer available - Contact david@neuromics.com with any questions Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy-terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by ERK, GSK-3 and CDK5. Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimer's disease and these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau. In particular, phosphorylation of Ser396 by GSK-3 or CDK5 destabilizes microtubules in Alzheimer's disease. Furthermore, inclusions of tau are found in a number of other neurodegenerative diseases, collectively known as tauopathies. |
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- Product Publications
Product Publications
- Roy B, Jackson GR. (2014). Interactions between Tau and α-synuclein augment neurotoxicity in a Drosophila model of Parkinson's disease. Hum Mol Genet. 23(11):3008-23. doi: 10.1093/hmg/ddu011
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Images
Tau-positive neurons (brown) in the hippocampus of a patient with Alzheimer's disease dilution of 1:1000) using Fluorescein (FITC)-labeled anti-Chicken IgY(1:500 dilution, Neuromics’ Catalog#:CH23101 ) as the secondary reagent.
Tau-positive neurons (brown) in the hippocampus of a patient with Alzheimer's disease dilution of 1:1000) using Fluorescein (FITC)-labeled anti-Chicken IgY(1:500 dilution, Neuromics’ Catalog#:CH23101 ) as the secondary reagent.