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| Size | List Price | Price | Cart |
|---|---|---|---|
| 100 ul | $325.00 | Add to Cart |
ALDH1L1 catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. ALDH1L1 expression is tissue-specific and is highly expressed in the liver. n an earlier study, Cahoy et al. applied FACS (Fluorescent-Activated Cell Sorting) to isolate astrocytes from EGFP (Enhanced Green Fluorescent Protein) transgenic-mouse, then created a transcriptome database of the expression levels of 20,000 genes by gene profiling of neurons, astrocytes and oligodedrocytes using Affymetrix GeneChip Arrays. They identified ALDH1L1 as a highly and specifically expressed gene in astrocytes. ALDH1L1 is more widely expressed throughout the brains, while astrocyte marker GFAP shows more predominant expression in white matter. In addition, loss of function or expression of ALDH1L1 is associated with decreased apoptosis, increased cell motility, and cancer progression, suggesting its role as a biomarker and a target in cancer therapy |
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- Product Publications
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- Jeff L. EllsworthI, Jacinthe Gingras, Laura J. Smith, Hillard Rubin, Tania A. Seabrook, Kruti Patel, Nicole Zapata, Kevin Olivieri, Michael O’Callaghan, Elizabeth ChlipalaI, Pablo Morales, Albert Seymour (2019). Clade F AAVHSCs cross the blood brain barrier and transduce the central nervous system in addition to peripheral tissues following intravenous administration in nonhuman primates PLoS ONE 14(11): e0225582. https://doi.org/10.1371/journal. pone.0225582
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Neuron-glial cell mixture cultures stained with ALDH1L1 (red) and our monoclonal antibody against GFAP (green). Blue is a DNA stain. ALDH1L1 stains astrocytes and excludes from neuron cells. ALDH1L1 stains the astrocytes cell body and processes, whereas GFAP labels the intermediate filament of the cytoskeleton in subset of astrocytes. Astrocytes are positive for both ALDH1L1 and GFAP appear yellow. ALDH1L1 also labels many astrocytes not labeled by GFAP, which appear as red.
Neuron-glial cell mixture cultures stained with ALDH1L1 (red) and our monoclonal antibody against GFAP (green). Blue is a DNA stain. ALDH1L1 stains astrocytes and excludes from neuron cells. ALDH1L1 stains the astrocytes cell body and processes, whereas GFAP labels the intermediate filament of the cytoskeleton in subset of astrocytes. Astrocytes are positive for both ALDH1L1 and GFAP appear yellow. ALDH1L1 also labels many astrocytes not labeled by GFAP, which appear as red.
Blot of rat liver tissure homogenates blotted with ALDH1L1. The antibody binds strongly a band at ~100 kDa.
Blot of rat liver tissure homogenates blotted with ALDH1L1. The antibody binds strongly a band at ~100 kDa.