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| Size | List Price | Price | Cart |
|---|---|---|---|
| 100 ul | $303.00 | Add to Cart |
Human GFAP is a 49,749 dalton protein (432 amino acids) expressed in astrocytes. GFAP is an intermediate filament protein and acts as an intracellular structural component of the cytoskeleton. During embryonic and fetal life, GFAP is also expressed by radial glial cells of the CNS. Various mutations of the GFAP gene in humans produce Alexander's disease, one of the leukodystrophies. Antibodies to GFAP are therefore very useful as markers of astrocytic cells and neural stem cells. In addition many types of brain tumor, presumably derived from astrocytic cells, heavily express GFAP. Product Highlights: |
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- Soo-Jeong Kim, Jae-Bong Kim, Seonghui Ham, and Sang Myun Park. (2024). Uncovering the Role of c-Fos in the Bidirectional Relationship Between Depression/Anxiety Behaviors and α-Synuclein Propagation in Parkinson's Disease. Research Square. doi: 10.21203/rs.3.rs-4997066/v1
- Jeehyun Yoo, Ji Cheol Shin, Kil-Byung Lim, Se Hoon Kim, Hyun Seok Kim, Sung Hoon Kim, Dawoon Baek, Seongmoon Jo, Jinyoung Kim, Ahreum Baek, and Sung-Rae Cho. (2024). Exposure to an Enriched Environment Modulates the Synaptic Vesicle Cycle in a Mouse Spinal Cord Injury Model. Scientific Reports, 14:11946. doi: 10.1038/s41598-024-62112-0
- Jae-Bong Kim, Soo-Jeong Kim, Minyoung So, Dong-Kyu Kim, Hye Rin Noh, Beom Jin Kim, Yu Ree Choi, Doyoon Kim, Heejung Koo, Taeyong Kim, Hyun Goo Woo, and Sang Myun Park. (2024). Artificial Intelligence-Driven Drug Repositioning Uncovers Efavirenz as a Modulator of α-Synuclein Propagation: Implications in Parkinson’s Disease. Biomedicine & Pharmacotherapy, 174:116442. doi: 10.1016/j.biopha.2024.116442
- Jae-Bong Kim, Yujeong Kim, Soo-Jeong Kim, Tae‑Young Ha, Dong-Kyu Kim, Dong Won Kim, Minyoung So, Seung Ho Kim, Hyun Goo Woo, Dukyong Yoon, and Sang Myun Park. (2023). Integration of National Health Insurance Claim Data and Animal Models Reveals Fexofenadine as a Promising Repurposed Drug for Parkinson’s Disease. Research Square. doi: 10.21203/rs.3.rs-3604108/v1
- Soo Jin Park, Uram Jin, and Sang Myun Park. (2021). Interaction Between Coxsackievirus B3 Infection and α-Synuclein in Models of Parkinson’s Disease. PLoS Pathogens, 17(10): e1010018. doi: 10.1371/journal.ppat.1010018
- M. Vassilakopoulou, M. Won, W.J. Curran, L. Souhami, M.D. Prados, C.J. Langer, D.L. Rimm, J.A. Hanna, V.M. Neumeister, E. Melian, A.Z. Diaz, J.N. Atkins, L.T. Komarnicky, C.J. Schultz, S.P. Howard, P. Zhang, A.P. Dicker, and J.P.S. Knisely. (2021). BRCA1 Protein Expression Predicts Survival in Glioblastoma Patients from an NRG Oncology RTOG Cohort. Oncology: 1-9. doi: 10.1159/000516168
- Rayul Wi, Young Cheul Chung, and Byung Kwan Jin. (2020). Functional Crosstalk Between CB and TRPV1 Receptors Protects Nigrostriatal Dopaminergic Neurons in the MPTP Model of Parkinson’s Disease. Journal of Immunology Research. doi: 10.1155/2020/5093493
- Hyun-Ju Lee, Hanwoong Woo, Ha-Eun Lee, Hyongjun Jeon, Ka-Young Ryu, Jin Han Nam, Seong Gak Jeon, Hyun Hee Park, Ji-Soo Lee, Kyung-Min Han, Sang Min Lee, Jeongyeon Kim, Ri-Jin Kang, Young-Ho Lee, Jae-Ick Kim, Hyang-Sook Hoe. (2020). The Novel DYRK1A Inhibitor KVN93 Regulates Cognitive Function, Amyloid-Beta Pathology, and Neuroinflammation. Free Radical Biology and Medicine. doi: 10.1016/j.freeradbiomed.2020.08.030
- Sora Kang, Ying Piao, Young Cheol Kang, Suyeol Lim, and Youngmi Kim Pak. (2020). Qi-Activating Quercetin Alleviates Mitochondrial Dysfunction and Neuroinflammation In Vivo and In Vitro. Archives of Pharmacal Research. doi: 10.1007/s12272-020-01238-x
- S. Jeon, S. Kim, S. Ha, S. Lee, E. Kim, S.Y. Kim, S.H. Park, J.H. Jeon, S.W. Kim, C. Moon, B.J. Nelson, J.Y. Kim, S.W. Yu, and H. Choi. (2019). Magnetically Actuated Microrobots as a Platform for Stem Cell Transplantation. Science Robotics, Vol. 4, Issue 30. doi: 10.1126/scirobotics.aav4317
- Abram Akopian, Sandeep Kumar, Hariharasubramanian Ramakrishnan, Kaushambi Roy, Suresh Viswanathan, and Stewart A. Bloomfield. (2017). Targeting neuronal gap junctions in mouse retina offers neuroprotection in glaucoma. J Clin Invest., doi: 10.1172/JCI91948
- Insup Choi, Dong-Joo Choi, Haijie Yang, Joo Hong Woo, Mi-Yoon Chang, Joo Yeon Kim, Woong Sun, Sang-Myun Park, Ilo Jou, Sang-Hun Lee and Eun-Hye Joe. (2016). PINK1 expression increases during brain development and stem cell differentiation, and affects the development of GFAP-positive astrocytes. Molecular Brain, 20169:5; doi: 10.1186/s13041-016-0186-6
- Wook Ha Park, Sora Kang, Ying Piao, Christine Jeehye Pak, Myung Sook Oh, Jinwoong Kim, Min Seo Kang, Youngmi Kim Pak. (2015). Ethanol extract of Bupleurum falcatum Linne and saikosaponins inhibit neuroinflammation via inhibition of NF-κB. Journal of Ethnopharmacology, doi: 10.1016/j.jep.2015.07.039
- Madhumitha Ravikumara, Smrithi Sunila, James Black, Deborah S. Barkauskas, e, Alex Y. Haung, Robert H. Miller, Stephen M. Selkirk, Jeffrey R. Capadona. (2014). The roles of blood-derived macrophages and resident microglia in the neuroinflammatory response to implanted Intracortical microelectrodes. Biomaterials. Volume 35, Issue 28, September 2014, Pages 8049–8064. doi: 10.1016/j.biomaterials.2014.05.084
- Frances Y. Cheng, Xi Huang, Anuraag Sarangi, Tatiana Ketova, Michael K. Cooper, Ying Litingtung, Chin Chiang. (2012). Widespread Contribution of Gdf7 Lineage to Cerebellar Cell Types and Implications for Hedgehog-Driven Medulloblastoma Formation. PLoS ONE, 7(4): e35541. doi: 10.1371/journal.pone.0035541
- David J. Gifondorwa, Mac B. Robinson, Crystal D. Hayes, Anna R. Taylor, David M. Prevette, Ronald W. Oppenheim, James Caress, and Carolanne E. Milligan. (2007). Exogenous Delivery of Heat Shock Protein 70 Increases Lifespan in a Mouse Model of Amyotrophic Lateral Sclerosis. The Journal of Neuroscience, doi: 10.1523/JNEUROSCI.4057-07.2007
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Images
Mixed neuron-glial cultures stained with rabbit GFAP (red channel) and chicken vimentin (green channel). The fibroblastic cells contain only vimentin and so are green, while astrocytes contain either vimentin and GFAP, so appearing golden, or predominantly GFAP, in which case they appear red. Blue is nuclear DNA stain. Protocol on data-sheet
Mixed neuron-glial cultures stained with rabbit GFAP (red channel) and chicken vimentin (green channel). The fibroblastic cells contain only vimentin and so are green, while astrocytes contain either vimentin and GFAP, so appearing golden, or predominantly GFAP, in which case they appear red. Blue is nuclear DNA stain. Protocol on data-sheet
Injection of rhHsp70 did not result in overt changes in glial cell activation. Lumbar spinal cord tissue was collected from treated and untreated G93A SOD1 or WT mice on P90. Twenty-five micrograms of protein per lane was loaded into each lane and Western blotting was performed to assess relative levels of GFAP and Iba1. When normalized to actin, quantification of the bands confirmed no change in expression (data not shown). doi:10.1523/JNEUROSCI.4057-07.2007
Injection of rhHsp70 did not result in overt changes in glial cell activation. Lumbar spinal cord tissue was collected from treated and untreated G93A SOD1 or WT mice on P90. Twenty-five micrograms of protein per lane was loaded into each lane and Western blotting was performed to assess relative levels of GFAP and Iba1. When normalized to actin, quantification of the bands confirmed no change in expression (data not shown). doi:10.1523/JNEUROSCI.4057-07.2007
Human Schwann Cells (cat no. HMP303) stained with GFAP (RA22101, red fluorescence) with DAPI (blue) counterstain
Human Schwann Cells (cat no. HMP303) stained with GFAP (RA22101, red fluorescence) with DAPI (blue) counterstain