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Out of stock - Currently unavailable Substance P is a neuropeptide derived from preprotachinin. Substance P is widely distributed in the central and peripheral nervous system. In sensory ganglia, it is expressed by small sensory neurons and is transported to their central and peripheral terminals. The role of substance P in sensory transmission has been studied extensively, and its involvement in nociception and chronic pain is well established. Our guinea pig anti-substance P antibody provides an excellent tool for multicolor immunofluorescence experiments. Product Highlights: |
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Product Publications
- Elora Midavaine, Rebecca L. Brouillette, Elizabeth Theberge, Christine E. Mona, Sakeen W. Kashem, Jerome Cote, Vera Zeugin, Elie Besserer-Offroy, Jean-Michel Longpre, Eric Marsault, and Philippe Sarret. (2024). Discovery of a CCR2-Targeting Pepducin Therapy for Chronic Pain. Pharmacological Research, 107242. doi: 10.1016/j.phrs.2024.107242
- Juan Miguel Jimenez-Andrade Martha B. Ramírez-Rosas, Sun Hee Park, Renee Parker, Matthew R. Eber, Rebecca Cain, Mary Newland, Fang-Chi Hsu, Carol A. Kittel, Thomas J. Martin, Enriqueta Muñoz-Islas, Yusuke Shiozawa, and Christopher M. Peters. (2023). Evaluation of Pain Related Behaviors and Disease Related Outcomes in an Immunocompetent Mouse Model of Prostate Cancer Induced Bone Pain. Journal of Bone Oncology, 100510. doi: 10.1016/j.jbo.2023.100510
- Shufang He, Vanessa O. Zambelli, Pritam Sinharoy, Laura Brabenec, Yang Bian, Freeborn Rwere, Rafaela C.R. Hell, Beatriz Stein Neto, Barbara Hung, Xuan Yu, Meng Zhao, Zhaofei Luo, Chao Wu, Lijun Xu, Katrin J. Svensson, Stacy L. McAllister, Creed M. Stary, Nana-Maria Wagner, Ye Zhang, and Eric R. Gross. (2022). A Human TRPV1 Genetic Variant within the Channel Gating Domain Regulates Pain Sensitivity in Rodents. The Journal of Clinical Investigation. doi: 10.1172/JCI163735.
- Sergio Benitez, Alicia Seltzer, Diego Messina, Mabel Foscolo, Sean Patterson, Christian Acosta. (2019). Cutaneous Inflammation Differently Regulates the Expression and Function of Angiotensin II Types 1 and 2 Receptors in Rat Primary Sensory Neurons. Journal of Neurochemistry. doi: 10.1111/jnc.14848
- José Eduardo Roa-Coria, Jorge Baruch Pineda-Farias, Paulino Barragán-Iglesias, Geovanna Nallely Quiñonez-Bastidas, Ángel Zúñiga-Romero, Juan Carlos Huerta-Cruz, Juan Gerardo Reyes-García, Francisco Javier Flores-Murrieta, Vinicio Granados-SotoView ORCID ID profile and Héctor Isaac Rocha-González (2019). Possible involvement of peripheral TRP channels in the hydrogen sulfide-induced hyperalgesia in diabetic rats. BMC Neuroscience 201920:1 https://doi.org/10.1186/s12868-018-0483-3
- William Haskinsa, Sergio Benitez, Juan M. Mercado, Cristian G. Acosta. (2017). Cutaneous inflammation regulates THIK1 expression in small C-like nociceptor dorsal root ganglion neurons. Molecular and Cellular Neuroscience, Volume 83, Pages 13–26. doi: 10.1016/j.mcn.2017.06.010
- Paulino Barragán-Iglesias, Hector I. Rocha-González, Jorge Baruch Pineda-Farias, Janet Murbartián, Beatriz Godínez-Chaparro, Peter S. Reinach, Thiago M. Cunha, Fernando Q. Cunha, Vinicio Granados-Soto. (2014). Inhibition of peripheral anion exchanger 3 decreases formalin-induced pain, European Journal of Pharmacology, doi: 10.1016/j.ejphar.2014.05.029
- Katherine E. Brandao, Mark L. Dell’Acqua and S. Rock Levinson. (2012). A-Kinase Anchoring Protein 150 Expression in a Specific Subset of TRPV1- and CaV1.2-Positive Nociceptive Rat Dorsal Root Ganglion Neurons. The Journal of Comparative Neurology, Volume 520, Issue 1. doi: 10.1002/cne.22692
- Gabriela Castaneda-Corral, Héctor I. Rocha-González, Beatriz Godínez-Chaparro, Juan Miguel Jiménez-Andrade, Vinicio Granados-Soto. (2011). Role of the spinal Na+/H+ exchanger in formalin-induced nociception. Neuroscience Letters, 501 4–9. doi: 10.1016/j.neulet.2011.06.048
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Images
Immuofluorescent detection of Affinity Purified Substance P in rat DRG (red fluorescence).
Immuofluorescent detection of Affinity Purified Substance P in rat DRG (red fluorescence).
Rat dorsal root ganglion cells were stained with guinea pig Substance P antibody (1:200-1:600) in red, and co-stained with DAPI in blue.
Rat dorsal root ganglion cells were stained with guinea pig Substance P antibody (1:200-1:600) in red, and co-stained with DAPI in blue.
SP staining of rat spinal cord dorsal horn. Neuroscience Letters Volume 501, Issue 1, 21 August 2011, Pages 4-9.
SP staining of rat spinal cord dorsal horn. Neuroscience Letters Volume 501, Issue 1, 21 August 2011, Pages 4-9.
Rat spinal cord dorsal horn cells were stained with guinea pig Substance P antibody (1:200-1:600) in red, and co-stained with DAPI in blue.
Rat spinal cord dorsal horn cells were stained with guinea pig Substance P antibody (1:200-1:600) in red, and co-stained with DAPI in blue.
Immuofluorescent detection of Affinity Purified Substance P in rat spinal cord dorsal horn (red fluorescence).
Immuofluorescent detection of Affinity Purified Substance P in rat spinal cord dorsal horn (red fluorescence).