Product Details
Product Sizes
| Size | List Price | Price | Cart |
|---|---|---|---|
| 100 ul | $380.00 | Add to Cart | |
| 50 ul | $210.00 | Add to Cart |
Neuropeptide Y (NPY) receptors are members of a G protein-coupled receptor superfamily and they mediate a variety of physiological responses including feeding and vasoconstriction. The endogenous ligands of NPY receptors are a family of structurally related peptides, including NPY, peptide YY (PYY), and pancreatic polypeptide (PP). Increased activity of NPY and its receptors, Y1R, Y2R, and Y5R has been found in the brain in many forms of experimental obesity. Furthermore, several association studies have supported the association between NPY2R and obesity. This NPY Y2 antibody has been extensively characterized in the spinal cord, brain, and distal colon. Product Highlights: |
Supporting Products
| Name | Catalog # | Size |
|---|---|---|
| NPY Y2 Receptor | P14112 | 50 ul. @ 2 mgs/ml Blocking Peptide |
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- Product Publications
Product Publications
- Jonathan W. Lovelace, Jingrui Ma, Saurabh Yadav, Karishma Chhabria, Hanbing Shen, Zhengyuan Pang, Tianbo Qi, Ruchi Sehgal, Yunxiao Zhang, Tushar Bali, Thomas Vaissiere, Shawn Tan, Yuejia Liu, Gavin Rumbaugh, Li Ye, David Kleinfeld, Carsen Stringer, and Vineet Augustine. (2023). Vagal Sensory Neurons Mediate the Bezold–Jarisch Reflex and Induce Syncope. Nature. doi: 10.1038/s41586-023-06680-7
- Chunxiao Yang, Zihua Gong, Xiaochen Zhang, Shuai Miao, Bozhi Li, Wei Xie, Tao Wang, Xun Han, Liang Wang, Zhao Dong, and Shengyuan Yu. (2023). Neuropeptide Y in the Medial Habenula Alleviates Migraine-Like Behaviors through the Y1 Receptor. The Journal of Headache and Pain, 24, 61. doi: 10.1186/s10194-023-01596-z
- Jason U. Tilan, Congyi Lu, Susana Galli, Ewa Izycka-Swieszewska, Joshua Patrick Earnest, Asim Shabbir, Lindsay M. Everhart, Shuo Wang, Samantha Martin, Meredith Horton, Akanksha Mahajan, David Christian, Alison O’Neill, Hongkun Wang, Tingting Zhuang, Magdalena Czarnecka, Michael D. Johnson, Jeffrey A. Toretsky, and Joanna Kitlinska. (2013). Hypoxia Shifts Activity of Neuropeptide Y in Ewing Sarcoma from Growth-Inhibitory to Growth-Promoting Effects.Oncotarget, 4:2487-2501. doi: 10.18632/oncotarget.1604
- Catherine Corrine Theisen. (2020). Targeting the Neuropeptide Y System in the Locus Coeruleus: Implications for Therapeutic Interventions in Opioid Use Disorders. Drexel University, doctoral dissertation.
- Tyler S. Nelson, Weisi Fu, Renée R. Donahue, Gregory F. Corder, Tomas Hökfelt, Ronald G. Wiley & Bradley K. Taylor. (2019). Facilitation of neuropathic pain by the NPY Y1 receptor-expressing subpopulation of excitatory interneurons in the dorsal horn. Scientific Reports volume 9, Article number: 7248. https://doi.org/10.1038/s41598-019-43493-z
- Elisabeth Dum , Sabine Fürtinger, Elisabeth Gasser, Anneliese Bukovac, Meinrad Drexel, Ramon Tasan, Günther Sperk. (2016). Effective G-protein coupling of Y2 receptors along axonal fiber tracts and its relevance for epilepsy. Neuropeptides, doi: 10.1016/j.npep.2016.10.005
- Angela M Sparrow, Emily G Lowery-Gionta, Kristen E Pleil, Chia Li, Gretchen M Sprow, Benjamin R Cox, Jennifer A Rinker, Ana M Jijon, José Peňa, Montserrat Navarro, Thomas L Kash and Todd E Thiele. (2012). Central Neuropeptide Y Modulates Binge-Like Ethanol Drinking in C57BL/6J Mice via Y1 and Y2 Receptors. Neuropsychopharmacology, doi: 10.1038/npp.2011.327
- Andres Acosta, Maria D. Hurtado, Oleg Gorbatyuk, Michael La Sala, David Duncan, George Aslanidi, Martha Campbell-Thompson, Lei Zhang, Herbert Herzog, Antonis Voutetakis, Bruce J. Baum, Sergei Zolotukhin. (2011). Salivary PYY: A Putative Bypass to Satiety. PLoS ONE, 6(10): e26137. doi: 10.1371/journal.pone.0026137
- Davor Stanić, Jan Mulder, Masahiko Watanabe, Tomas Hökfelt. (2011). Characterization of NPY Y2 receptor protein expression in the mouse brain. II. Coexistence with NPY, the Y1 receptor, and other neurotransmitter-related molecules. The Journal of Comparative Neurology, Volume 519, Issue 7, pages 1219–1257. doi: 10.1002/cne.22608
- Robina Matyal, Feroze Mahmood, Michael Robich, Hiliary Glazera, Kamal Khabbaza, Philip Hessa, Cesario Bianchia, Robert Hagberga, Shu-Xu Hua, and Frank W. Sellkea. (2011). Chronic type II diabetes mellitus leads to changes in neuropeptide Y receptor expression and distribution in human myocardial tissue. European Journal of Pharmacology, Volume 665, Issues 1-3, Pages 19-28. doi: 10.1016/j.ejphar.2011.04.039
- Galina Burdyga, Andrea Varro, Rod Dimaline, David G. Thompson, and Graham J. Dockray. (2010). Expression of cannabinoid CB1 receptors by vagal afferent neurons: kinetics and role in influencing neurochemical phenotype. Am J Physiol Gastrointest Liver Physiol, 299: G63 - G69. doi: 10.1152/ajpgi.00059.2010
- Lixin Wang, Guillaume Gourcerol, Pu-Qing Yuan, S. Vincent Wu, Mulugeta Million, Muriel Larauche, and Yvette Taché. (2009). Peripheral peptide YY inhibits propulsive colonic motor function through Y2 receptor in conscious mice. Am J Physiol Gastrointest Liver Physiol, doi: 10.1152/ajpgi.00349.2009
- Galina Burdyga, Guillaume de Lartigue, Helen E. Raybould, Richard Morris, Rod Dimaline, Andrea Varro, David G. Thompson, and Graham J. Dockray. (2008). Cholecystokinin Regulates Expression of Y2 Receptors in Vagal Afferent Neurons Serving the Stomach. The Journal of Neuroscience, 28(45):11583-11592. doi: 10.1523/JNEUROSCI.2493-08.2008
- Brumovsky P, Stanic D, Shuster S, Herzog H, Villar M, Hokfelt T. (2005). Neuropeptide Y2 receptor protein is present in peptidergic and nonpeptidergic primary sensory neurons of the mouse. J Comp Neurol., 489(3):328-48. doi: 10.1002/cne.20639
- J. Victor Nadlera, Bin Tu, Olga Timofeevaa, Yiqun Jiao and Herbert Herzog. (2007). Neuropeptide Y in the recurrent mossy fiber pathway. Peptides, doi: 10.1016/j.peptides.2006.07.026
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Images
NPY Y2 receptor immunoreactivity in mouse dorsal root ganglion of wild type (A) and NPY Y2 receptor Knockout (B) animals. Note that unspecific staining is observed in thick, possibly myelinated fibers. Image courtesy of Dr. Tomas Hökfelt, Karolinska Institute.
NPY Y2 receptor immunoreactivity in mouse dorsal root ganglion of wild type (A) and NPY Y2 receptor Knockout (B) animals. Note that unspecific staining is observed in thick, possibly myelinated fibers. Image courtesy of Dr. Tomas Hökfelt, Karolinska Institute.
CCK regulates expression of Y2R in vagal afferent neurons. The Journal of Neuroscience, November 5, 2008, 28(45):11583-11592; doi:10.1523/JNEUROSCI.2493-08.2008
CCK regulates expression of Y2R in vagal afferent neurons. The Journal of Neuroscience, November 5, 2008, 28(45):11583-11592; doi:10.1523/JNEUROSCI.2493-08.2008