Product Details
Catalog Number: CH22103
Applications: ICC, WB, IHC
Type: Chicken IgY
Dilutions: ICC 1:10,000; IHC 1:10,000; WB 1:100,000
Immunogen: Recombinant human projection domain sequence, amino acids 377-1505
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (polar packs)
Format A: liquid
Species Reactivity: Human, Mouse, Rat, Primate
Entrez: 4133
UniProt: P11137
RRID: AB_2314763
Downloads: Datasheet (pdf)
Product Sizes
| Size | List Price | Price | Cart |
|---|---|---|---|
| 50 ul | $329.00 | Add to Cart |
Microtubules are associated with a family of proteins called microtubule associated proteins (MAPs), which includes the protein tau and a group of proteins referred to as MAP1, MAP2, MAP3, MAP4, and MAP5. MAP2 is made up of two ~280kDa apparent molecular weight bands referred to as MAP2a and MAP2b. A third lower molecular weight form, usually called MAP2c, corresponds to a pair of protein bands running at ~70kDa on SDS-PAGE gels. All these MAP2 forms are derived from a single gene by alternate transcription, and all share a C-terminal sequence which includes either three or four microtubule-binding peptide sequences, which are very similar to those found in the related microtubule binding protein tau. MAP2 isoforms are expressed only in neuronal cells and specifically in the perikarya and dendrites of these cells. Antibodies to MAP2 are therefore excellent markers on neuronal cells, their perikarya and neuronal dendrites. In contrast, tau is found predominantly in neuronal axons. |
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- Product Publications
Product Publications
- Jessica Root, Anarmaa Mendsaikhan, Georgia Taylor, Paola Merino, Srijita Nandy, Minzheng Wang, Ludmilla Troiano Araujo, Danny Ryu, Christopher Holler, Bonne M. Thompson, Giuseppe Astarita, Jean-François Blain, and Thomas Kukar. (2024). Granulins Rescue Inflammation, Lysosome Dysfunction, Lipofuscin, And Neuropathology in a Mouse Model of Progranulin Deficiency. Cell Reports, 43(12): 114985. doi: 10.1016/j.celrep.2024.114985
- Sonia R. Weimann, Chao Zhang, and R. Michael Burger. (2024). A Developmental Switch in Cholinergic Mechanisms of Modulation in the Medial Nucleus of the Trapezoid Body. The Journal of Neuroscience, 44(8): e0356232023. doi: 10.1523/JNEUROSCI.0356-23.2023
- Larissa Traxler, Joseph R. Herdy, Davide Stefanoni, Sophie Eichhorner, Silvia Pelucchi, Attila Szücs, Alice Santagostino, Yongsung Kim, Ravi K. Agarwal, Johannes C.M. Schlachetzki, Christopher K. Glass, Jessica Lagerwall, Douglas Galasko, Fred H. Gage, Angelo D’Alessandro, and Jerome Mertens. (2022). Warburg-Like Metabolic Transformation Underlies Neuronal Degeneration in Sporadic Alzheimer’s Disease. Cell Metabolism. doi: 10.1016/j.cmet.2022.07.014
- Nikhil J. Pandya, Congwei Wang, Veronica Costa, Paul Lopatta, Sonja Meier, F. Isabella Zampeta, A. Mattijs Punt, Edwin Mientjes, Philip Grossen, Tania Distler, Manuel Tzouros. Yasmina Marti, Balazs Banfai, Christoph Patsch, Soren Rasmussen. Marius Hoener, Marco Berrera, Thomas Kremer, Tom Dunkley, Martin Ebeling, Ben Distel, Ype Elgersma, and Ravi Jagasia. (2021). Secreted Retrovirus-Like GAG-Domain-Containing Protein PEG10 is Regulated by UBE3A and is Involved in Angelman Syndrome Pathophysiology. Cell Reports Medicine. 2(8). doi: 10.1016/j.xcrm.2021.100360
- Carina Lund, Venkatram Yellapragada, Sanna Vuoristo, Diego Balboa, Sara Trova, Cecile Allet, Nazli Eskici, Kristiina Pulli, Paolo Giacobini, Timo Tuuri, and Taneli Raivio. (2020). Characterization of the Human GnRH Neuron Developmental Transcriptome Using a GNRH1-TdTomato Reporter Line in Human Pluripotent Stem Cells. Disease Models & Mechanism, The Company of Biologists Ltd. doi: 10.1242/dmm.040105
- Delwen L. Franzen, Sarah A. Gleiss, Christian J. Kellner, Nikolaos Kladisios, Felix Felmy (2020). Activity-dependent calcium signaling in neurons of the medial superior olive during late postnatal development. Journal of Neuroscience 16 January 2020, 1545-19; DOI: 10.1523/JNEUROSCI.1545-19.2020
- Elisabeth Rosner, Boris P. Chagnaud, Mario F. Wullimann. (2019). Serotonin systems in three socially communicating teleost species, the grunting toadfish (Allenbatrachus grunniens), a South American marine catfish (Ariopsis seemannii), and the upside-down catfish (Synodontis nigriventris). Journal of Chemical Neuroanatomy. https://doi.org/10.1016/j.jchemneu.2019.101708
- Victor Naumov, Julia Heyd, Fauve de Arnal, and Ursula Koch (2019). Analysis of excitatory and inhibitory neuron types in the inferior colliculus based on Ih properties. Journal of Neurophysiology. https://doi.org/10.1152/jn.00594.2018
- Siveke, I., Ammer, J. J., Gleiss, S. A., Grothe, B., Leibold, C. and Felmy, F. (2018), Electrogenic NMDA receptor signaling enhances binaural responses in the adult brainstem. Eur J Neurosci. Accepted Author Manuscript. doi:10.1111/ejn.13859
- Brittney L Gurda, PhD, VMD Jessica H Bagel, DVM Samantha J Fisher, BS Mark L Schultz, PhD Andrew P Lieberman, MD, PhD Peter Hand, VMD, PhD Charles H Vite, DVM, PhD Gary P Swain, PhD. (2018). LC3 Immunostaining in the Inferior Olivary Nuclei of Cats With Niemann-Pick Disease Type C1 Is Associated With Patterned Purkinje Cell Loss. Journal of Neuropathology & Experimental Neurology, nlx119, https://doi.org/10.1093/jnen/nlx119
- Sonja Brosel, Benedikt Grothe, and Lars Kunz. (2017). An auditory brainstem nucleus as a model system for neuronal metabolic demands. European Journal of Neuroscience. DOI: 10.1111/ejn.13789
- Elisabet Garcia-Pino, Nikodemus Gessele and Ursula Koch. (2017). Enhanced Excitatory Connectivity and Disturbed Sound Processing in the Auditory Brainstem of Fragile X Mice. Journal of Neuroscience, 2310-16; doi: 10.1523/JNEUROSCI.2310-16.2017
- Anna Lisa Gündner Claas Aiko Meyera, Stefan Aigner, Klaus Christensen, Christoph Patsch, Ravi Jagasia, Karlheinz Baumann, Marc Burcin. (2017). Generation of a homozygous GBA deletion human embryonic stem cell line. Stem Cell Research, doi: 10.1016/j.scr.2017.07.009
- Matthew J. Fischl, R. Michael Burger, Myriam Schmidt-Pauly, Olga Alexandrova, James Langley Sinclair, Benedikt Grothe, Ian D Forsythe, Conny Kopp-Scheinpflug. (2016). Physiology and Anatomy of Neurons in the Medial Superior Olive (MSO) of the Mouse. Journal of Neurophysiology, doi: 10.1152/jn.00523.2016
- Allison M. Bradbury, Tiffany A. Peterson, Amanda L. Gross, Stephen Z. Wells, Victoria J. McCurdy, Karen G. Wolfe, John C. Dennis, Brandon L. Brunson, Heather Gray-Edwards, Ashley N. Randle, Aime K. Johnson, Edward E. Morrison, Nancy R. Cox, Henry J. Baker, Miguel Sena-Esteves, Douglas R. Martin. (2016). AAV Mediated Gene Delivery Attenuates Neuroinflammation in Feline Sandhoff Disease. Neuroscience, doi: 10.1016/j.neuroscience.2016.10.047
- Matthew J. Fischl, R. Michael Burger, Myriam Schmidt-Pauly, Olga Alexandrova, James Langley Sinclair, Benedikt Grothe, Ian D Forsythe, Conny Kopp-Scheinpflug. (2016). Physiology and Anatomy of Neurons in the Medial Superior Olive (MSO) of the Mouse. Journal of Neurophysiology, doi: 10.1152/jn.00523.2016
- Shweta Hegde, Will R Capell, Baher A Ibrahim, Jennifer Klett, Neema S Patel, Alexander T Sougiannis and Michy P Kelly. (2016). Phosphodiesterase 11A (PDE11A), Enriched in Ventral Hippocampus Neurons, is Required for Consolidation of Social but not Nonsocial Memories in Mice. Neuropsychopharmacology, doi: 10.1038/npp.2016.106
- S. Jacobs, C. Cheng, L.C. Doering. (2016). Hippocampal neuronal subtypes develop abnormal dendritic arbors in the presence of Fragile X astrocyte. Neuroscience, Volume 324, Pages 202-217. doi: 10.1016/j.neuroscience.2016.03.011
- Gessele N, Garcia-Pino E, Omerbašić D,Park TJ, Koch U. (2016). Structural Changes and Lack of HCN1 Channels in the Binaural Auditory Brainstem of the Naked Mole-Rat (Heterocephalus glaber. PLoS ONE, 11(1): e0146428, doi: 10.1371/journal.pone.0146428
- Majid Ebrahimi, Yui Yamamoto, Kazem Sharifi, Hiroyuki Kida, Yoshiteru Kagawa, Yuki Yasumoto, Ariful Islam, Hirofumi Miyazaki, Chie Shimamoto, Motoko Maekawa, Dai Mitsushima, Takeo Yoshikawa and Yuji Owada. (2015). Astrocyte-expressed FABP7 regulates dendritic morphology and excitatory synaptic function of cortical neurons. Glia, doi: 10.1002/glia.22902
- Bethany L. Johnson-Kerner, Faizzan S. Ahmad, Alejandro Garcia Diaz, John Palmer Greene, Steven J. Gray, Richard Jude Samulski, Wendy K. Chung, Rudy Van Coster, Paul Maertens, Scott A. Noggle, Christopher E. Henderson, and Hynek Wichterle. (2015). Intermediate filament protein accumulation in motor neurons derived from giant axonal neuropathy iPSCs rescued by restoration of gigaxonin. Hum. Mol. Genet., 24: 1420 - 1431. doi: 10.1093/hmg/ddu556
- Radtke-schuller S, Seeler S and Grothe B. (2015). Restricted loss of olivocochlear but not vestibular efferent neurons in the senescent gerbil (Meriones unguiculatus). Front. Aging Neurosci, 7:4. doi: 10.3389/fnagi.2015.00004
- Delwen L Franzen, Sarah A Gleiss, Christina Berger, Franziska S Kümpfbeck, Julian J Ammer, Felix Felmy. (2014). Development and modulation of intrinsic membrane properties control the temporal precision of auditory brainstem neurons. Journal of Neurophysiology, doi: 10.1152/jn.00601.2014
- Bethany L. Johnson-Kerner, Faizzan S. Ahmad, Alejandro Garcia Diaz, J. Palmer Greene, Steven J. Gray, R. Jude Samulski, Wendy K. Chung, Rudy Van Coster, Paul Maertens, Scott A. Noggle, Christopher E. Henderson and Hynek Wichterle. (2014). Intermediate filament protein accumulation in motor neurons derived from giant axonal neuropathy iPSCs rescued by restoration of gigaxonin. Hum. Mol. Genet., doi: 10.1093/hmg/ddu556
- Qiudong Deng, Christopher J. Holler, Georgia Taylor, Kathryn F. Hudson, William Watkins, Marla Gearing, Daisuke Ito, Melissa E. Murray, Dennis W. Dickson, Nicholas T. Seyfried, and Thomas Kukar. (2014). FUS is Phosphorylated by DNA-PK and Accumulates in the Cytoplasm after DNA Damage. Neurobiology of Disease | The Journal of Neuroscience, 34(23):7802-7813; doi: 10.1523/JNEUROSCI.0172-14.2014
- Simon Lehnert, Marc C. Ford, Olga Alexandrova, Franziska Hellmundt, Felix Felmy, Benedikt Grothe, and Christian Leibold. (2014). Action Potential Generation in an Anatomically Constrained Model of Medial Superior Olive Axons. The Journal of Neuroscience, 34(15): 5370-5384; doi: 10.1523/JNEUROSCI.4038-13.2014
- Bin Xing, Adam D. Bachstetter, Linda J. Van Eldik. (2014). Inhibition of Neuronal p38α, but not p38β MAPK, Provides Neuroprotection Against Three Different Neurotoxic Insults. Journal of Molecular Neuroscience, doi: 10.1007/s12031-014-0372-x
- Simon Lehnert, Marc C. Ford, Olga Alexandrova, Franziska Hellmundt, Felix Felmy, Benedikt Grothe, and Christian Leibold. (2014). Action Potential Generation in an Anatomically Constrained Model of Medial Superior Olive Axons. Articles - Systems/Circuits The Journal of Neuroscience, 34(15):5370-5384; doi: 10.1523/JNEUROSCI.4038-13.2014
- Qiudong Deng, Christopher J. Holler, Georgia Taylor, Kathryn F. Hudson, William Watkins, Marla Gearing, Daisuke Ito, Melissa E. Murray, Dennis W. Dickson, Nicholas T. Seyfried, and Thomas Kukar. (2014). FUS is Phosphorylated by DNA-PK and Accumulates in the Cytoplasm after DNA Damage. Neurobiology of Disease | The Journal of Neuroscience, 34(23):7802-7813; doi: 10.1523/JNEUROSCI.0172-14.2014
- Baumann Veronika, Lehnert Simon, Leibold Christian, Koch Ursula. (2013). Tonotopic Organization of the Hyperpolarization-activated Current (Ih) in the Mammalian Medial Superior Olive. Front. Neural Circuits 7:117. Front Neural Circuits, doi: 10.3389/fncir.2013.00117
- Kiri Couchman, Benedikt Grothe and Felix Felmy. (2010). Medial Superior Olivary Neurons Receive Surprisingly Few Excitatory and Inhibitory Inputs with Balanced Strength and Short-Term Dynamics. The Journal of Neuroscience, 30(50):17111-17121; doi: 10.1523/JNEUROSCI.1760-10.2010
- Benjamin Hassfurth, Benedikt Grothe and Ursula Koch. (2010). The Mammalian Interaural Time Difference Detection Circuit Is Differentially Controlled by GABAB Receptors during Development. The Journal of Neuroscience, 30(29):9715-9727. doi: 10.1523/JNEUROSCI.1552-10.2010
- Shelley Jacobs and Laurie C. Doering. (2010). Astrocytes Prevent Abnormal Neuronal Development in the Fragile X Mouse. J. Neurosci., 30: 4508 - 4514 ; doi: 10.1523/JNEUROSCI.5027-09.2010
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Images
Confocal image of adult rat cerebellar cortex stained with VSNL1 (CH22132, green) and chicken polyclonal antibody to MAP2 (red) and DNA (blue). VSNL1 antibody reveals synapses in the molecular layer (ML) strongly. Synaptic regions are also seen in the granule cell layer (GC). The perikarya of Purkinje cells (PC) are revealed with the MAP2 antibody (4). Little staining is seen in the white matter (WM).
Confocal image of adult rat cerebellar cortex stained with VSNL1 (CH22132, green) and chicken polyclonal antibody to MAP2 (red) and DNA (blue). VSNL1 antibody reveals synapses in the molecular layer (ML) strongly. Synaptic regions are also seen in the granule cell layer (GC). The perikarya of Purkinje cells (PC) are revealed with the MAP2 antibody (4). Little staining is seen in the white matter (WM).
primary neuronal culture showing neuronal staining with MAP2 (green; Catalog # CH22103) and astrocytes with GFAP (red; Catalog # MO19063). Nuclei are counterstained blue.
primary neuronal culture showing neuronal staining with MAP2 (green; Catalog # CH22103) and astrocytes with GFAP (red; Catalog # MO19063). Nuclei are counterstained blue.