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| Size | List Price | Price | Cart |
|---|---|---|---|
| 100 ul | $275.00 | Add to Cart |
Transient receptor potential ion channels (TRPCs) are a superfamily of six transmembrane segment-spanning, gated cation channels. TRPA1 is a TRP-related channel that responds to cold temperatures and pungent compounds and plays a role in both nociceptor and hair cell transduction. It is a transformation-associated gene product in lung epithelia, whereas its protein distribution is primarily restricted to sensory neurons. Blocking TRPA1 may be a therapeutic target for treating cold hyperalgesia caused by inflammation and nerve damage. It is now known that TRPA1 protein is also widely expressed outside of the CNS and is dys-regulated during oncogenic transformation. Product Highlights: |
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Product Publications
- Mayur J. Patil, Margaux Salas, Siarhei Bialuhin, Jacob T. Boyd, Nathaniel A. Jeske, Armen N. Akopian. (2019). Sensitization of small‐diameter sensory neurons is controlled by TRPV1 and TRPA1 association. The FASEB Journal. https://doi.org/10.1096/fj.201902026R
- Sarah Krupp. (2016). Effects of neonatal capsaicin on formalin-induced ATF3 expression in the adult rat. University of Louisville, ThinkIR: The University of Louisville's Institutional Repository Electronic Theses and Dissertations. doi: 10.18297/etd/2535
- Yun Sook Kim, PhD, Hoon Kap Jung, DDS, Tae Kyung Kwon, DDS, Chin Soo Kim, DDS, PhD, Jin Hyun Cho, DDS, PhD, Dong Kuk Ahn, DDS, PhD, Yong Chul Bae, DDS, PhD. (2012). Expression of Transient Receptor Potential Ankyrin in Human Dental Pulp. Journal of Endodontics, doi: 10.1016/j.joen.2012.04.024
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Images
TRPA1 staining of rat DRG using FITC-conjugated donkey anti-rabbit secondary antibodies (green color) and propidium iodide as a counterstain.
TRPA1 staining of rat DRG using FITC-conjugated donkey anti-rabbit secondary antibodies (green color) and propidium iodide as a counterstain.
Immunofluorescent staining for (A) TRPA1 in the human normal dental pulp is completely abolished by (B) preadsorption with a control peptide, proving the specificity of the TRPA1 antiserum (×200, scale bars = 50 μm). doi.org/10.1016/j.joen.2012.04.024.
Immunofluorescent staining for (A) TRPA1 in the human normal dental pulp is completely abolished by (B) preadsorption with a control peptide, proving the specificity of the TRPA1 antiserum (×200, scale bars = 50 μm). doi.org/10.1016/j.joen.2012.04.024.