Product Details
Catalog Number: RA10104
Applications: ICC, WB, IHC
Type: Rabbit IgG
Immunogen: NHQLENLEAETAPLP
Storage: Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Whole serum
Format B: liquid
Species Reactivity: Human, Mouse, Rat, Primate
Entrez: 4988
UniProt: P35372
RRID: AB_2156526
Downloads: Datasheet (pdf)
Product Sizes
| Size | List Price | Price | Cart |
|---|---|---|---|
| 150 ul | $360.00 | Add to Cart | |
| 50 ul | $155.00 | Add to Cart |
Three types of opioid receptors have been cloned -- mu, delta, and kappa. Opioid receptors are seven transmembrane G-protein coupled receptors. They share a high degree of homology and are most divergent at the N- and C-termini. Activation of mu opioid receptors leads to a decrease in neuronal excitability. Product Highlights: |
Supporting Products
| Name | Catalog # | Size |
|---|---|---|
| Mu Opioid Receptor Blocking Peptide | P10104 | 50 ul Blocking Peptide @ 2mgs/ml |
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- Product Publications
Product Publications
- Kelsey Vollmer, Lisa Green, Roger Grant, Kion Winston, Elizabeth Doncheck, Christopher Bowen, Jacqueline Paniccia, Rachel Clarke, Annika Tiller, Preston Siegler, Benjamin Siemsen, Adam Denton, Thomas Jhou, Jennifer Rinker, Michael Scoeld, and James Otis. (2022). A Thalamostriatal Parvalbumin Interneuron Circuit Suppresses Risky Reward-Motivated Behaviors and Is Disengaged by Opioids. doi: 10.21203/rs.3.rs-1527325/v1
- Amanda Lillywhite, Stephen G. Woodhams, Sara V. Goncalves, David J.G. Watson, Li Li, James J. Burston, Peter R.W. Gowler,, Meritxell Canals, David A. Walsh, Gareth J. Hathway, Victoria Chapman. (2021). Anxiety Enhances Pain In a Model of Osteoarthritis and Is Associated with Altered Endogenous Opioid Function and Reduced Opioid Analgesia. Pain Reports. doi: 10.1097/PR9.0000000000000956
- Ching Chang, Hung-Kai Liu, Chao-Bin Yeh, Ming-Lin Yang, Wen-Chieh Liao Chiung-Hui Liu, and To-Jung Tseng. (2021). Cross-Talk of Toll-Like Receptor 5 and Mu-Opioid Receptor Attenuates Chronic Constriction Injury-Induced Mechanical Hyperalgesia through a Protein Kinase C Alpha-Dependent Signaling. International Journal of Molecular Sciences, 22(4), 189. doi: 10.3390/ijms22041891
- Yize Li, Xinying Guo, Linlin Sun, Jifang Xiao, Songxue Su, Shibin Du, Zhen Li, Shaogen Wu, Weili Liu, Kai Mo, Shangzhou Xia, Yun‐Juan Chang, Daniel Denis, and Yuan‐Xiang Tao. (2020). N6‐Methyladenosine Demethylase FTO Contributes to Neuropathic Pain by Stabilizing G9a Expression in Primary Sensory Neurons. Advanced Science. doi: 10.1002/advs.201902402
- Xiaqing Ma, Rui Chen, Min Huang, Wenying Wang, Limin Luo, Dong Kwan Kim, Wei Jiang, and Tao Xuab. (2020). DAMGO-Induced μ Opioid Receptor Internalization and Recycling Restore Morphine Sensitivity in Tolerant Rat. European Journal of Pharmacology. doi: 10.1016/j.ejphar.2020.173118
- Caroline Johnson, Weizhe Hong and Paul Micevych (2020). Optogenetic activation of β-endorphin terminals in the medial preoptic nucleus regulates sexual receptivity. eNeuro 15 January 2020, ENEURO.0315-19.2019; DOI: https://doi.org/10.1523/ENEURO.0315-19.2019
- Jie Sun, Shao-Rui Chen, Hui-Lin Pan (2020). μ-Opioid receptors in primary sensory neurons are involved in supraspinal opioid analgesia. Brain Research Volume 1729, https://doi.org/10.1016/j.brainres.2019.146623
- Batsheva Reich Yan Zhou Ellen Goldstein Sudarshan S. Srivats Natalina H. Contoreggi Joshua F. Kogan Bruce S. McEwen Mary Jeanne Kreek Teresa A. Milner Jason D. Gray (2019). Chronic immobilization stress primes the hippocampal opioid system for oxycodone associated learning in female but not male rats. Synapse. Accepted Author Manuscript. doi:10.1002/syn.22088
- Jie Sun Shao‐Rui Chen Hong Chen Hui‐Lin Pan. (2018). μ‐Opioid receptors in primary sensory neurons are essential for opioid analgesic effect on acute and inflammatory pain and opioid‐induced hyperalgesia. The Journal of Physiology. https://doi.org/10.1113/JP277428
- Min-Ho Nam, Kyung-Seok Han, Jaekwang Lee, Jin Young Bae, Heeyoung An, Seahyung Park, Soo-Jin Oh, Eunju Kim, Eunmi Hwang, Yong Chul Bae, and C. Justin Lee. (2018). Expression of µ-Opioid Receptor in CA1 Hippocampal Astrocytes. Exp Neurobiol. 2018 Apr;27(2):120-128. English. Published online April 24, 2018. https://doi.org/10.5607/en.2018.27.2.120
- Fenghua Bao, Chang-Lin Li, Xu-Qiao Chen, Ying-Jin Lu, Lan Bao, and Xu Zhang. (2018). Clinical Opioids Differentially Induce Co-Internalization of μ- and δ-Opioid Receptors. Molecular Pain. doi: https://doi.org/10.1177/1744806918769492
- TJ Tseng, ML Yang, YL Hsieh, MH Ko, ST Hsieh. (2017). Nerve Decompression Improves Spinal Synaptic Plasticity of Opioid Receptors for Pain Relief. Neurotoxicity Research, doi: 10.1007/s12640-017-9799-5
- Wendy M. Walwyn, Wenling Chen, Hyeyoung Kim, Ani Minasyan, Helena S. Ennes, James A. McRoberts, and Juan Carlos G. Marvizón. (2016). Sustained Suppression of Hyperalgesia during Latent Sensitization by μ-, δ-, and κ-opioid receptors and α2A Adrenergic Receptors: Role of Constitutive Activity. The Journal of Neuroscience, 36(1): 204-221. doi: 10.1523/JNEUROSCI.1751-15.2016
- Sherika N. Smith, Candler Paige, Kandy T. Velazquez, Terika P. Smith, Srinivasa N. Raja, Steven P. Wilson, Sarah M. Sweitzer. (2015). Injury-specific promoters enhance herpes simplex virus mediated gene therapy for treating neuropathic pain in rodents. The Journal of Pain, doi: 10.1016/j.jpain.2014.12.007
- Fiona B Carr, Sandrine M Géranton and Stephen P Hunt. (2014). Descending controls modulate inflammatory joint pain and regulate CXC chemokine and iNOS expression in the dorsal horn. Molecular Pain, 10:39. doi: 10.1186/1744-8069-10-39
- Shafaq Sikandar, Kirsty Bannister, Anthony H. Dickenson. (2012). Brainstem facilitations and descending serotonergic controls contribute to visceral nociception but not pregabalin analgesia in rats. Neuroscience Letters, doi: 10.1016/j.neulet.2012.05.009
- Andrew C. Eschenroeder, Allison A. Vestal-Laborde, Emilse S. Sanchez, Susan E. Robinson, Carmen Sato-Bigbee. (2012). Oligodendrocyte responses to buprenorphine uncover novel and opposing roles of μ-opioid- and nociceptin/orphanin FQ receptors in cell development: Implications for drug addiction treatment during pregnancy. Glia, Volume 60, Issue 1, pages 125–136. doi: 10.1002/glia.21253
- De Felice, Milena, Sanoja, Raul, Wang, Ruizhong, Vera-Portocarrero, Louis, Oyarzo, Janice, King, Tamara, Ossipov, Michael H., Porreca, Frank. (2011). Engagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain. PAIN, 152 (12), p.2701-2709. doi: 10.1016/j.pain.2011.06.008
- Ryan J. Horvathab, Alfonso Romero-Sandoval, Joyce A. De Leo. (2010). Inhibition of microglial P2X4 receptors attenuates morphine tolerance, Iba1, GFAP and μ opioid receptor protein expression while enhancing perivascular microglial ED2. PAIN, Pages 401-413. doi: 10.1016/j.pain.2010.02.042
- Hai-Bo Wanga, Bo Zhaoa, Yan-Qing Zhonga, Kai-Cheng Li, Zi-Yan Li, Qiong Wang, Yin-Jing Lua, Zhen-Ning Zhang, Shao-Qiu He, Han-Cheng Zheng, Sheng-Xi Wu, Tomas G. M. Hökfelt, Lan Baob, and Xu Zhanga. (2010). Coexpression of δ- and μ-opioid receptors in nociceptive sensory neurons. PNAS, vol. 107 no. 29 13117-13122. doi: 10.1073/pnas.1008382107
- Marta Pinto, Marta Sousa, Deolinda Lima, Isaura Tavares. (2008). Participation of mu-opioid, GABAB, and NK1 receptors of major pain control medullary areas in pathways targeting the rat spinal cord: Implications for descending modulation of nociceptive transmission. The Journal of Comparative Neurology, Volume 510, Issue 2, Pages 175 - 187. doi: 10.1002/cne.21793
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Images
Double immunofluorescence labeling showing the presence of a subpopulation of spinal lamina II neurons that contained both µ opioid receptor (green) and TRPV1 (red) immunoreactivity in a vehicle (A)- and a RTX (B)-treated rats. Scale bar, 20 µm. More information found: J Neurophysiol 95: 3086-3096, 2006. First published February 8, 2006; doi:10.1152/jn.01343.2005 0022-3077
Double immunofluorescence labeling showing the presence of a subpopulation of spinal lamina II neurons that contained both µ opioid receptor (green) and TRPV1 (red) immunoreactivity in a vehicle (A)- and a RTX (B)-treated rats. Scale bar, 20 µm. More information found: J Neurophysiol 95: 3086-3096, 2006. First published February 8, 2006; doi:10.1152/jn.01343.2005 0022-3077
MOR staining of Rat DRG (dilution: 1:100) incubation at 4 °C overnight. Secondary antibody is anti-Rabbit Rhodamine Red (dilution:1:200) incubation at room temperature for 1 hour.
MOR staining of Rat DRG (dilution: 1:100) incubation at 4 °C overnight. Secondary antibody is anti-Rabbit Rhodamine Red (dilution:1:200) incubation at room temperature for 1 hour.