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| Size | List Price | Price | Cart |
|---|---|---|---|
| 100 ul | $409.00 | Add to Cart |
Glutamine Synthetase, also called glutamate-ammonia ligase (GLUL), is expressed throughout the body and plays an important role in controlling body pH and in removing ammonia from the circulation. The enzyme clears L-glutamate, the major neurotransmitter in the central nervous system, from neuronal synapses. Its activity is decreased in the cerebral cortex of brains affected by Alzheimer's disease, particularly in the vicinity of senile plaques. It is also decreased under conditions of glucose deprivation. The level of expression of Glutamine Synthetase is increased during ischemia in vivo or hypoxia in culture. |
Images
Localization of glutamine synthase in the retina. Paraffin sections of mouse (A, B), rat (C, D, G-I), or human (E, F) retina fixed in 4% paraformaldehyde were reacted with anti-glutamine synthase (red fluorescence staining in B, D, G, I, and brown immuno-peroxidase reaction [using ABC kit and visualization with DAB product in F].
Western blot analysis of glutamine synthase. 40ug of lysates from mouse (lane M), rat (lane R), pig (lane P), bovine (lane B), or human (lane Hu) retina were probed. A 34 kDa band was identified.