Product Details
Catalog Number: RA22123
Applications: ICC, WB, IHC, IF
Type: Rabbit IgG
Immunogen: Synthetic peptides from aa 471-486 of human MeCP2
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat
Entrez: 4204
UniProt: P51608
Downloads: Datasheet (pdf)
Product Sizes
| Size | List Price | Price | Cart |
|---|---|---|---|
| 100 ul | $325.00 | Add to Cart |
Methyl-CpG Binding Protein 2 (MeCP2) is a nuclear protein that is found to bind to symmetrical methylated CpG dinucleotide sequences. It is a transcriptional modulator that can alter gene expression epigenetically via binding to methylated DNA. It is involved not only in transcriptional silencing, but also in transcriptional activation, chromatin remodeling, and RNA splicing. Mecp2is a X-chromosome-linked gene, highly expressed in neurons. |
Images
Mouse brain section, which was cut at 45μm on a vibratome after perfusion with 4% paraformaldehyde and overnight fixation, was stained with polyclonal antibody: RA22123. MeCP2 was mainly associated with methylated DNA in nucleus of neuron cells (green). Blue shows DAPI staining of nuclear DNA.