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| Size | List Price | Price | Cart |
|---|---|---|---|
| 100 ul | $559.00 | Add to Cart |
PGP9.5 is a soluble cytoplasmic protein with a molecular weight of approximately 25,000 kD. It is present in neurons and in cells of the diffuse neuroendocrine system. PGP9.5 functions as a tissue-specific ubiquitin carboxyl-terminal hydrolase isoenzyme. This enzyme is also known as UCH-L1. Because of its abundance in nerves, it has been widely used as a marker for peripheral nerve fibers. It was also discovered as a gene mutated in some rare familial forms of Parkinson's disease. Interestingly a common allelic variant of UCHL1, the S18Y polymorphism is actually protective against Parkinson's disease. It is also a marker for cells of the diffuse neuroendocrine system and their tumors. |
Images
The PGP mouse that we received from Neuromics works fantastically! I used it at 1:100 with Cy3 at 1:500 and got great staining with good background levels. PGP9.5 staining of Rat Abdominal Tissue. Courtesy of Jamie Nugent (Dr. Marna Ericson's Lab), University of Minnesota.