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Tyrosine hydroxylase is involved in the conversion of phenylalanine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. Tyrosine hydroxylase is regularly used as a marker for dopaminergic neurons, which is particularly relevant for research into Parkinson's disease. |
Images
TH staining of human mid-brain. Note cytoplasmic staining of catecholaminergic cells and their processes. Paraffin section (Peroxidase substrate: nickel DAB, Counterstain: eosin).
Immunoperoxidase (A and C) and immunofluorescent (B, D–H) labeling of intrinsic cardiac adrenergic (ICA) cells in human hearts are shown. Scale bars = 10 µm, except in B (20 µm). More information: Am J Physiol Heart Circ Physiol 293: H376-H384, 2007