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Currently out of stock - contact david@neuromics.com for more information Musashi1, a neural RNA-binding protein, plays an important role in regulating cell differentiation in precursor cells. Musashi-1 (Msi-1) has been shown to increase the accumulation of tau isoforms in intracellular inclusions in dementia and Parkinson's. The presence of Msi-1 in a significant percentage of neurons containing cytoplasmic inclusions in 2 other neurodegenerative diseases Alzheimer's disease and Pick disease suggests that it may play a role in the pathogenesis of these neurodegenerative disorders. Musashi1 has also been detected in human tumor tissues such as gliomas and melanomas, suggesting its involvement in cancer development. Msi-1 also appears to play be an vital role in the development of several types of carcinoma such as human hepatoma, and may be a useful molecular marker for tumor detection. |
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- Seung Ah Choi, Eun Jung Koh, Ryong Nam Kim, Jung Woo Byun, Ji Hoon Phi, Jeyul Yang, Kyu-Chang Wang, Ae Kyung Park, Do Won Hwang, Ji Yeoun Lee, and Seung-Ki Kim. (2020). Extracellular Vesicle-Associated miR-135b and -135a Regulate Stemness in Group 4 Medulloblastoma Cells by Targeting Angiomotin-Like 2. Cancer Cell International, 20, 558. doi: 10.1186/s12935-020-01645-6
- Amanda K. Silva, Hyun Yi, Sarah H. Hayes, Gail M. Seigel, Abigail S. Hackam. (2010). Lithium chloride regulates the proliferation of stem-like cells in retinoblastoma cell lines: a potential role for the canonical Wnt signaling pathway. Molecular Vision 2010; 16:36-45.
- Min-Tsai Liu, Yung-Hui Kuan, Jingwen Wang, René Hen, and Michael D. Gershon. (2009). 5-HT4 Receptor-Mediated Neuroprotection and Neurogenesis in the Enteric Nervous System of Adult Mice. The Journal of Neuroscience, August 5, 2009, 29(31):9683-9699; doi: 10.1523/JNEUROSCI.1145-09.2009
- Sujoy K. Dhara, Kowser Hasneen, David W. Machacek, Nolan L. Boyd, Raj R. Rao, Steven L. Stice. (2008). Human neural progenitor cells derived from embryonic stem cells in feeder-free cultures. Differentiation, 76 (5), 454–464. doi: 10.1111/j.1432-0436.2007.00256.x
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Images
Musashi (green) staining of neural rosettes(human). Nuclei are counterstained blue (DAPI). Image courtesy of Drs. Patricia Wilson and Steve Stice, University of Georgia.
Musashi (green) staining of neural rosettes(human). Nuclei are counterstained blue (DAPI). Image courtesy of Drs. Patricia Wilson and Steve Stice, University of Georgia.
Musashi-positive cells in the ventricular zone of E14.5 mouse medulla. Picture was taken at 200x magnification. The sections are 4% PFA fixed, paraffin-embedded and cut at 5 micron. Courtesy of Xi Huang, Chiang Lab, VUMC.
Musashi-positive cells in the ventricular zone of E14.5 mouse medulla. Picture was taken at 200x magnification. The sections are 4% PFA fixed, paraffin-embedded and cut at 5 micron. Courtesy of Xi Huang, Chiang Lab, VUMC.
RB116 cells stained with Musashi-1 at 15 μg/ml
RB116 cells stained with Musashi-1 at 15 μg/ml
Immunostaining of hNP1 Progenitors before and after differentiation. The culture was highly homogenous with neural rosettes. DOI: 10.1111/j.1432-0436.2007.00256.x.
Immunostaining of hNP1 Progenitors before and after differentiation. The culture was highly homogenous with neural rosettes. DOI: 10.1111/j.1432-0436.2007.00256.x.