Product Details
Currently out of stock - contact david@neuromics.com for more information TRPV1 antagonists have shown efficacy in reducing nociception from inflammatory and neuropathic pain models in rats.[11] This provides evidence that TRPV1 is the capsaicin's sole receptor. In humans, drugs acting at TRPV1 receptors could potentially be used to treat neuropathic pain associated with multiple sclerosis, chemotherapy, or amputation, as well as pain associated with the inflammatory response of damaged tissue, such as in osteoarthritis.
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Supporting Products
| Name | Catalog # | Size |
|---|---|---|
| VR1 C-Terminus (TRPV1) - mouse specific | P14113 | 100 ug Blocking Peptide |
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- Product Publications
Product Publications
- Md Nabiul Islam, Naoki Maeda, Emi Miyasato, Mir Rubayet Jahan, Abu Md Mamun Tarif, Taiga Ishino, Kanako Nozaki, Koh-Hei Masumoto, Akie Yanai, and Koh Shinoda. (2020). Expression of Huntingtin-Associated Protein 1 in Adult Mouse Dorsal Root Ganglia and its Neurochemical Characterization in Reference to Sensory Neuron Subpopulations. IBRO Reports, 9, 258-269. doi: 10.1016/j.ibror.2020.10.001
- Rahul Atmaramani. (2020). Development of an in vitro Phenotypic Assay for Screening Chronic Pain Therapeutics. University of Texas at Dallas, Doctoral Dissertation.
- Helen Kühn, Leonie Kappes, Katharina Wolf, Lisa Gebhardt, Markus F. Neurath, Peter Reeh, Michael J. M. Fischer, and Andreas E. Kremer. (2020). Complementary Roles of Murine Na V 1.7, Na V 1.8 and Na V 1.9 in Acute Itch Signalling. Scientific Reports, 10:2326. doi: 10.1038/s41598-020-59092-2
- Fengxian Li, Weishan Yang, Haowu Jiang, Changxiong Guo, Andrew J. W. Huang, Hongzhen Hu & Qin Liu (2019). TRPV1 activity and substance P release are required for corneal cold nociception. Nature Communications. https://doi.org/10.1038/s41467-019-13536-0
- Poitras, T., Chandrasekhar, A., McCoy, L. et al. (2019). Selective Sensory Axon Reinnervation and TRPV1 Activation. Mol Neurobiol https://doi.org/10.1007/s12035-019-1574-6
- Maria Cristina Marrone, Annunziato Morabito, Michela Giustizieri, Valerio Chiurchiù, Alessandro Leuti, Marzia Mattioli, Sara Marinelli, Loredana Riganti, Marta Lombardi, Emanuele Murana, Antonio Totaro, Daniele Piomelli, Davide Ragozzino, Sergio Oddi, Mauro Maccarrone, Claudia Verderio & Silvia Marinelli. (2017). TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice. Nature Communications, 8, Article number: 15292. doi: 10.1038/ncomms15292
- Danyou Hu, Changming Wang, Fengxian Li, et al. (2017). “A Combined Water Extract of Frankincense and Myrrh Alleviates Neuropathic Pain in Mice via Modulation of TRPV1,” Neural Plasticity, vol. 2017, Article ID 3710821, 11 pages. doi: 10.1155/2017/3710821
- Changming Wang, Zhongli Wang, Yan Yang, Chan Zhu, Guanyi Wu, Guang Yu, Tunyu Jian, Niuniu Yang, Hao Shi, Min Tang, Qian He, Lei Lan, Qin Liu, Yun Guan, Xinzhong Dong, Jinao Duan and Zongxiang Tang. (2015). Pirt contributes to uterine contraction-induced pain in mice. Molecular Pain, 11:57. doi: 10.1186/s12990-015-0054-x
- Carl Weitlauf, Nicholas J. Ward, Wendi S. Lambert, Tatiana N. Sidorova, Karen W. Ho, Rebecca M. Sappington, and David J. Calkins. (2014). Short-Term Increases in Transient Receptor Potential Vanilloid-1 Mediate Stress-Induced Enhancement of Neuronal Excitation. The Journal of Neuroscience, 34(46): 15369-15381. doi: 10.1523/JNEUROSCI.3424-14.2014
- Marics I, Malapert P, Reynders A, Gaillard S, Moqrich A. (2014). Acute Heat-Evoked Temperature Sensation Is Impaired but Not Abolished in Mice Lacking TRPV1 and TRPV3 Channels. PLoS ONE, 9(6): e99828. doi: 10.1371/journal.pone.0099828
- Dongyue Huang, Shuyang Li, Ajay Dhaka, Gina M Story and Yu-Qing Cao. (2012). Expression of the transient receptor potential channels TRPV1, TRPA1 and TRPM8 in mouse trigeminal primary afferent neurons innervating the dura. Molecular Pain, 8:66. doi: 10.1186/1744-8069-8-66
- Sarah E. Canetta, Edlira Luca, Elyse Pertot, Lorna W. Role, David A. Talmage. (2011). Type III Nrg1 Back Signaling Enhances Functional TRPV1 along Sensory Axons Contributing to Basal and Inflammatory Thermal Pain Sensation. PLoS ONE, 6(9): e25108. doi: 10.1371/journal.pone.0025108
- Julie A. Christianson, Klaus Bielefeldt, Sacha A. Malin and Brian M. Davis. (2010). Neonatal colon insult alters growth factor expression and TRPA1 responses in adult mice. Pain, Volume 151, Issue 2, Pages 540-549. doi: 10.1016/j.pain.2010.08.029
- Kenjiro Matsumoto, Emi Kurosawa, Hiroyuki Terui, Takuji Hosoya, Kimihito Tashima, Toshihiko Murayama, John V Priestley, and Syunji Horie. (2009). Localization of TRPV1 and contractile effect of capsaicin in mouse large intestine: high abundance and sensitivity in rectum and distal colon. Am J Physiol Gastrointest Liver Physiol, doi: 10.1152/ajpgi.90578.2008
- Rebecca M. Sappington, Tatiana Sidorova, Daniel J. Long, and David J. Calkins. (2009). TRPV1: Contribution to Retinal Ganglion Cell Apoptosis and Increased Intracellular Ca2+ with Exposure to Hydrostatic Pressure. Invest. Ophthalmol. Vis. Sci., 50: 717 - 728. doi: 10.1167/iovs.08-2321
- Ann M. Bode, Yong-Yeon Cho, Duo Zheng, Feng Zhu, Marna E. Ericson, Wei-Ya Ma, Ke Yao, and Zigang Dong. (2009). Transient Receptor Potential Type Vanilloid 1 Suppresses Skin Carcinogenesis. Cancer Res., 69: 905 - 913. doi: 10.1158/0008-5472.CAN-08-3263
- Jens Hjerling-Leffler, Mona AlQatari, Patrik Ernfors, and Martin Koltzenburg. (2007). Emergence of Functional Sensory Subtypes as Defined by Transient Receptor Potential Channel Expression. The Journal of Neuroscience, 27(10):2435–2443. doi: 10.1523/JNEUROSCI.5614-06.2007
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Images
A Confocal image stack through GCL and NFL of peripheral retina shows TRPV1 in retinal ganglion cell (RGC) bodies (bracket) and in small bundles of RGC axons (arrows). doi:10.1167/iovs.08-2321
A Confocal image stack through GCL and NFL of peripheral retina shows TRPV1 in retinal ganglion cell (RGC) bodies (bracket) and in small bundles of RGC axons (arrows). doi:10.1167/iovs.08-2321
VR1 immunoreactivity in mouse dorsal root ganglion. Animals were perfusion fixed with 2% paraformaldehyde. Image courtesy of Dr. Zunyi Wang, University of Wisconsin, Madison.
VR1 immunoreactivity in mouse dorsal root ganglion. Animals were perfusion fixed with 2% paraformaldehyde. Image courtesy of Dr. Zunyi Wang, University of Wisconsin, Madison.