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| Size | List Price | Price | Cart |
|---|---|---|---|
| 150 ul | $369.00 | Add to Cart | |
| 50 ul | $165.00 | Add to Cart |
PGP9.5 is a soluble cytoplasmic protein with a molecular weight of approximately 25,000 kD. It is present in neurons and in cells of the diffuse neuroendocrine system. PGP9.5 functions as a tissue-specific ubiquitin carboxyl terminal hydrolase isoenzyme. This enzyme is also known as UCH-L1. Because of its abundance in nerves, it has been widely used as a marker for peripheral nerve fibers. It was also discovered as a gene mutated in some rare famial forms of Parkinson's disease. Interestingly a common allelic variant of UCHL1, the S18Y polymorphism is actually protective against Parkinson's disease. It is also a marker for cells of the diffuse neuroendocrine system and their tumors. |
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Product Publications
- Marie Hanscom, Wilmarie Morales-Soto, Stephanie W Watts, William F. Jackson, and Brian D. Gulbransen. (2024). Innervation of Adipocytes is Limited in Mouse Perivascular Adipose Tissue. American Journal of Physiology-Heart and Circulatory Physiology. doi: 10.1152/ajpheart.00041.2024
- Diego N. Messina, Emanuel D. Peralta, and Cristian G. Acosta. (2023). Complex Alterations in Inflammatory Pain and Analgesic Sensitivity in Young and Ageing Female Rats: Involvement of ASIC3 and Nav1.8 in Primary Sensory Neurons. Research Square. doi: 10.21203/rs.3.rs-3433175/v1
- Dalia Halawani, Yiqun Wang, Aarthi Ramakrishnan, Molly Estill, Xijing He, Li Shen, Roland H. Friedel, and Hongyan Zou. (2023). Circadian Clock Regulator Bmal1 Gates Axon Regeneration via Tet3 Epigenetics in Mouse Sensory Neurons. Nature Communications 14, 5165. doi: 10.1038/s41467-023-40816-7
- Yuuki Shirai, Junko Okano, Takahiko Nakagawa, Miwako Katagi, Yuki Nakae, Atsuhiro Arakawa, Shinya Koshinuma, Gaku Yamamoto, and Hideto Kojima. (2022). Bone Marrow-Derived Vasculogenesis Leads to Scarless Regeneration in Deep Wounds with Periosteal Defects. Scientific Reports, 12:20589. doi: 10.1038/s41598-022-24957-1
- Sergio Benitez, Alicia Seltzer, Diego Messina, Mabel Foscolo, Sean Patterson, Christian Acosta. (2019). Cutaneous Inflammation Differently Regulates the Expression and Function of Angiotensin II Types 1 and 2 Receptors in Rat Primary Sensory Neurons. Journal of Neurochemistry. doi: 10.1111/jnc.14848
- Saban MR, Davis CA, Avelino A, Cruz F, Maier J, Bjorling DE, Sferra TJ, Hurst RE, Saban R. (2011). VEGF signaling mediates bladder neuroplasticity and inflammation in response to BCG. BMC Physiology, 11:16. doi: 10.1186/1472-6793-11-16
- Bianka Brunne, Shanting Zhao, Amin Derouiche, Joachim Herz, Petra May, Michael Frotscher, and Hans H. Bock. (2010). Origin, Maturation and Astroglial Transformation of Secondary Radial Glial Cells in the Developing Dentate Gyrus. Glia, 58(13): 1553–1569. doi: 10.1002/glia.21029
- M Ikeuchi, MD, PhD, SJ Kolker, LA Burnes, RY Walder, PhD, and KA Sluka, PT, PhD. (2008). Role of ASIC3 in the primary and secondary hyperalgesia produced by joint inflammation in mice. Pain, doi: 10.1016/j.pain.2008.01.020
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PGP9.5 staining of epithelial cells in porcine distal colon. Nerve fibers immunoreactive for the neural marker PGP 9.5 (red) are in close proximity to both IgA-immunoreactive plasma cells (green) and epithelial cells immunoreactive for SC (blue) in the colonic crypts. Abbreviations: Cr, colonic crypt; L, intestinal lumen; SM, submucosa. Scale bars: A, 100 μm. J Neuroimmunol. Published online 2007 February 21. doi: 10.1016
PGP9.5 staining of epithelial cells in porcine distal colon. Nerve fibers immunoreactive for the neural marker PGP 9.5 (red) are in close proximity to both IgA-immunoreactive plasma cells (green) and epithelial cells immunoreactive for SC (blue) in the colonic crypts. Abbreviations: Cr, colonic crypt; L, intestinal lumen; SM, submucosa. Scale bars: A, 100 μm. J Neuroimmunol. Published online 2007 February 21. doi: 10.1016
PGP9.5 staining of rat DRGs (Dilution 1:500)
PGP9.5 staining of rat DRGs (Dilution 1:500)