Product Details
Catalog Number: RA10109
Applications: ICC, WB, IHC, FC
Type: Rabbit IgG
Storage: Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Whole serum
Format B: liquid
Species Reactivity: Human, Rat, Primate
Entrez: 5024
UniProt: P56373
RRID: AB_2157931
Downloads: Datasheet (pdf)
Out of stock - Currently unavailable P2X3 is a subunit in the family of ion channels activated by extracellular ATP. It was cloned from rat dorsal root ganglia. P2X3 has two putative transmembrane domains with intracellular N- and C-termini. It can form homomeric channels and heteromeric channels with other members of the family. P2X3 is expressed in nociceptive sensory neurons. Product Highlights: |
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- Product Publications
Product Publications
- Hao-Hao Chen, Muhammad Mohsin, Jia-Yi Ge, Yu-Ting Feng, Jing-Ge Wang, Yu-Sen Ou, Zuo-Jie Jiang, Bo-Ya Hu, and Xing-Jun Liu. (2023). Optogenetic Activation of Peripheral Somatosensory Neurons in Transgenic Mice as a Neuropathic Pain Model for Assessing the Therapeutic Efficacy of Analgesics. ACS Pharmacology & Translational Science. doi: 10.1021/acsptsci.3c00254
- Takuya Yokoyama, Masato Hirakawa, Kei Mochizuki, Takashi Suzuki, Katsumi Nakajima, and Tomoyuki Saino. (2023). Distribution of P2X3 Purinoceptor-Immunoreactive Sensory Nerve Endings in the Carotid Body of Japanese Macaque (Macaca Fuscata). Anatomical Science International. doi: 10.1007/s12565-023-00735-5
- Masato Hirakawa, Takuya Yokoyama, Yoshio Yamamoto, and Tomoyuki Saino. (2021). Morphology of P2X3-Immunoreactive Basket-Like Afferent Nerve Endings Surrounding Serosal Ganglia and Close Relationship with Vesicular Nucleotide Transporter-Immunoreactive Nerve Fibers in the Rat Gastric Antrum. Journal of Comparative Neurology. doi: 10.1002/cne.25219
- Momoko Koizumi, Sayaka Asano, Akihiko Furukawa, Yoshinori Hayashi, Suzuro Hitomi, Ikuko Shibuta, Katsuhiko Hayashi, Fusao Kato, Koichi Iwata, and Masamichi Shinoda. (2021). P2X3 Receptor Upregulation in Trigeminal Ganglion Neurons Through TNFα Production in Macrophages Contributes to Trigeminal Neuropathic Pain in Rats. The Journal of Headache and Pain, 22, 31. doi: 10.1186/s10194-021-01244-4
- Yoshio Yamamoto, Takuya Yokoyama, and Nobuaki Nakamuta. (2021). Morphology of GNAT3‐Immunoreactive Chemosensory Cells in the Nasal Cavity and Pharynx of the Rat. Journal of Anatomy. doi: 10.1111/joa.13424.
- Yize Li, Xinying Guo, Linlin Sun, Jifang Xiao, Songxue Su, Shibin Du, Zhen Li, Shaogen Wu, Weili Liu, Kai Mo, Shangzhou Xia, Yun‐Juan Chang, Daniel Denis, and Yuan‐Xiang Tao. (2020). N6‐Methyladenosine Demethylase FTO Contributes to Neuropathic Pain by Stabilizing G9a Expression in Primary Sensory Neurons. Advanced Science. doi: 10.1002/advs.201902402
- Duan-Duan He, Yu Gao, Shan Wang, Zhong Xie, and Xue-Jun Song. (2020). Systematic Administration of B Vitamins Alleviates Diabetic Pain and Inhibits Associated Expression of P2X3 and TRPV1 in Dorsal Root Ganglion Neurons and Proinflammatory Cytokines in Spinal Cord in Rats. Pain Research and Management, 2020:3740162. doi: 10.1155/2020/3740162
- Yokoyama, T., Yamamoto, Y., Hirakawa, M., Kato, K. and Saino, T. (2019). Vesicular nucleotide transporter‐immunoreactive type I cells associated with P2X3‐immunoreactive nerve endings in the rat carotid body. J Comp Neurol. doi:10.1002/cne.24837
- Haruka Masuda Nobuaki Nakamuta Yoshio Yamamoto. (2018). Morphology of GNAT3‐immunoreactive chemosensory cells in the rat larynx. Journal of Anatomy https://doi.org/10.1111/joa.12914
- Peng-Fei Liu, Hong-Zhi Fang, Yan Yang, Qing-Qing Zhang, Qiang-Qiang Zhou, Song-Song Chen, Fang Zhou, Li-Cai Zhang. (2017). Activation of P2X3 receptors in the cerebrospinal fluid-contacting nucleus neurons reduces formalin-induced pain behavior via PAG in a rat model. Neuroscience, doi: 10.1016/j.neuroscience.2017.06.036
- Diana Sofia Marques Nascimento, Catarina Soares Potes, Miguel Luz Soares, António Carlos Ferreira, Marzia Malcangio, José Manuel Castro-Lopes, and Fani Lourença Moreira Neto. (2017). Drug-Induced HSP90 Inhibition Alleviates Pain in Monoarthritic Rats and Alters the Expression of New Putative Pain Players at the DRG. Mol Neurobiol, doi: 10.1007/s12035-017-0628-x
- Xing J. & Li J. (2016). Bradykinin Contributes to Sympathetic and Pressor Responses Evoked by Activation of Skeletal Muscle Afferents P2X in Heart Failure. Cell Physiol Biochem, 39:2101-2109. doi: 10.1159/000447906
- Sam M. Hermes, Michael C. Andresen, Sue A. Aicher. (2015). Localization of TRPV1 and P2X3 in unmyelinated and myelinated vagal afferents in the rat. Journal of Chemical Neuroanatomy, doi: 10.1016/j.jchemneu.2015.12.003
- Jianfei Guo, Xudong Fu, Xia Cui, Minhua Fan. (2014). Contributions of purinergic P2X3 receptors within the midbrain periaqueductal gray to diabetes-induced neuropathic pain. The Journal of Physiological Sciences, doi: 10.1007/s12576-014-0344-5
- Longchang Fan, Xiaowei Guan, Wei Wang, Jian-Yuan Zhao, Hongkang Zhang, Vinod Tiwari, Paul N Hoffman, Min Li and Yuan-Xiang Tao. (2014). Impaired neuropathic pain and preserved acute pain in rats overexpressing voltage-gated potassium channel subunit Kv1.2 in primary afferent neurons. Molecular Pain, 10:8. doi: 10.1186/1744-8069-10-8
- Suzy Krimon, Dionéia Araldi, Filipe César do Prado, Cláudia Herrera Tambeli, Maria Cláudia G. Oliveira-Fusaro, Carlos Amílcar Parada. (2013). P2X3 receptors induced inflammatory nociception modulated by TRPA1, 5-HT3 and 5-HT1A receptors. Pharmacology Biochemistry and Behavior, doi: 10.1016/j.pbb.2013.09.017
- F.C. Pradoa, D. Araldia, A.S. Vieiraa, M.C.G. Oliveira-Fusarob, C.H. Tambelia, C.A. Parada. (2013). Neuronal P2X3 receptor activation is essential to the hyperalgesia induced by prostaglandins and sympathomimetic amines released during inflammation. Neuropharmacology, doi: 10.1016/j.neuropharm.2012.11.011
- T. Cho, V. V. Chaban. (2012). Interaction Between P2X3 and Oestrogen Receptor (ER)α/ERβ in ATP-Mediated Calcium Signalling In Mice Sensory Neurones. Journal of Neuroendocrinology, Volume 24, Issue 5, pages 789–797. doi: 10.1111/j.1365-2826.2011.02272.x
- De Felice, Milena, Sanoja, Raul, Wang, Ruizhong, Vera-Portocarrero, Louis, Oyarzo, Janice, King, Tamara, Ossipov, Michael H., Porreca, Frank. (2011). Engagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain. PAIN, 152 (12), p.2701-2709. doi: 10.1016/j.pain.2011.06.008
- B. Huanga, X. Zhaoc, L.-B. Zhengb, L. Zhanga, B. Nia. (2011). Different expression of tissue inhibitor of metalloproteinase family members in rat dorsal root ganglia and their changes after peripheral nerve injury. Neuroscience, Volume 193, Pages 421-428. doi: 10.1016/j.neuroscience.2011.07.031
- Timothy K. Y. Kaan, Ping K. Yip, Sital Patel, Meirion Davies, Fabien Marchand, Debra A. Cockayne, Philip A. Nunn, Anthony H. Dickenson, Anthony P. D. W. Ford, Yu Zhong, Marzia Malcangio, and Stephen B. McMahon. (2010). Systemic blockade of P2X3 and P2X2/3 receptors attenuates bone cancer pain behaviour in rats. Brain, 133: 2549 - 2564. doi: 10.1093/brain/awq194
- Nathaniel A. Sowa, Bonnie Taylor-Blake, and Mark J. Zylka. (2010). Ecto-5'-Nucleotidase (CD73) Inhibits Nociception by Hydrolyzing AMP to Adenosine in Nociceptive Circuits. The Journal of Neuroscience, 30(6):2235-2244. doi: 10.1523/JNEUROSCI.5324-09.2010
- Michael A. Thacker, Anna K. Clark, Thomas Bishop, John Grist, Ping K. Yip, Lawrence D.F. Moon, Stephen W.N. Thompson, Fabien Marchand, Stephen B. McMahon. (2009). CCL2 is a key mediator of microglia activation in neuropathic pain states. European Journal of Pain, 13, 263–272. doi: 10.1016/j.ejpain.2008.04.017
- Sylvia Sarman; Jorge Mancini; Ingeborg van der Ploeg; J. Oscar Croxatto; Anders Kvanta; Juan E. Gallo. (2008). Involvement of Purinergic P2 Receptors in Experimental Retinal Neovascularization. Current Eye Research, doi: 10.1080/02713680701885470
- Ruizhong Wang, Tamara King, Michael H Ossipov, Anthony J Rossomando, Todd W Vanderah, Pamela Harvey, Peter Cariani, Eric Frank, Dinah W Y Sah, Frank Porreca. (2008). Persistent restoration of sensory function by immediate or delayed systemic artemin after dorsal root injury. Nature Communications, doi: 10.1038/nn2069
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Images
DRG sections double-labeled for ASIC3 (red) and either P2X3 (green, A) or TRPV1 (green, B); double-labeled cells are yellow or orange.
DRG sections double-labeled for ASIC3 (red) and either P2X3 (green, A) or TRPV1 (green, B); double-labeled cells are yellow or orange.
P2X3 Staining in Rat DRG. Working dilution 1:100 - 1:300.
P2X3 Staining in Rat DRG. Working dilution 1:100 - 1:300.