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| Size | List Price | Price | Cart |
|---|---|---|---|
| 100 ul | $325.00 | Add to Cart |
Fox3 is one of a family of 3 mammalian Fox homologues. Fox was discovered in C. elegans as a gene involved in sex determination, and the name Fox is an acronym of "Feminizing locus on X". The Fox protein and its 3 mammalian homologues are all about 46kDa proteins each of which includes a central highly conserved RRM type RNA recognition motif, which corresponds to a small ~70 amino acid structure consisting of 4 beta strands and two alpha-helices. An alternate name for Fox 3 is hexaribonucleotide binding protein 3, and these proteins are believed to have a role in the regulation of mRNA splicing. Much interest has focused on Fox3 as this protein corresponds to NeuN, a neuronal nuclear antigen. NeuN antibody has become very widely used as a robust marker of neurons and neuronal stem cells. Fox3 is therefore a protein which has a funciton in RNA splicing and is expressed heavily and specifically in neuronal nuclei. |
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Product Publications
- Heath Larsson Robinson. (2022). ERBB4 Kinase Dynamically Regulates Hippocampal-Prefrontal Synchrony and Hippocampal Sharp Wave Ripples Important for Attention and Memory. Case Western Reserve University Doctoral Dissertation.
- Jin-Xia Hu, Wei-Jing Ma, Li-Ying He, Cong-Hui Zhang, Cheng Zhang, Yan Wang, Chao-Nan Chen, Da-Yong Shen, Hui-Min Gao, Rui-Ru Guo, Qian-Qian Ning, Xin-Chun Ye, Gui-Yun Cui, and Lei Li. (2022). Macrophage Migration Inhibitory Factor (MIF) Acetylation Protects Neurons from Ischemic Injury. Cell Death & Disease, 13:466. doi: 10.1038/s41419-022-04918-2
- Kong-Yan Wu, Fu-Lei Tang, Daehoon Lee, Yang Zhao, Hyunjin Song, Xiao-Juan Zhu, Lin Mei and Wen-Cheng Xiong. (2020). Ependymal VPS35 Promotes Ependymal Cell Differentiation and Survival, Suppresses Microglial Activation, and Prevents Neonatal Hydrocephalus. Journal of Neuroscience. doi: 10.1523/JNEUROSCI.1520-19.2020
- Weike Deng, Fei Luo, Bao-ming Li, Lin Mei (2019). NRG1–ErbB4 signaling promotes functional recovery in a murine model of traumatic brain injury via regulation of GABA release. Experimental Brain Research. https://doi.org/10.1007/s00221-019-05680-2
- Sreyashi Samaddar, Kizzy Vazquez, Dipen Ponika, Pedro Toruno, Karim Sahbani, Sultana Begum, Ahmed Abouelela, Wagdy Mekhael, Zaghloul Ahmed. (2016). Trans-spinal direct current stimulation modulates migration and proliferation of adult newly-born spinal cells in mice. Journal of Applied Physiology, doi: 10.1152/japplphysiol.00834.2016
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Images
Rat brain neural cultures stained with FOX3/NeuN (red), and our chicken polyclonal antibody to GFAP (green) and DNA (blue). The FOX3 antibody reveals strong nuclear and distal cytoplasmic staining for Fox3/NeuN and the complete absence of staining of astrocytes, which are staining with the GFAP antibody, and other kinds of non-neuronal cells. Protocol on Data-sheet.
Rat brain neural cultures stained with FOX3/NeuN (red), and our chicken polyclonal antibody to GFAP (green) and DNA (blue). The FOX3 antibody reveals strong nuclear and distal cytoplasmic staining for Fox3/NeuN and the complete absence of staining of astrocytes, which are staining with the GFAP antibody, and other kinds of non-neuronal cells. Protocol on Data-sheet.
Cryosections form the spinal cord of a mouse stained with NeuN//Fox3 (Cat#MO22122) Top at 10X Bottom at 20X. Courtesy of Dr Sreyashi Samaddar at College of Staten Island
Cryosections form the spinal cord of a mouse stained with NeuN//Fox3 (Cat#MO22122) Top at 10X Bottom at 20X. Courtesy of Dr Sreyashi Samaddar at College of Staten Island
Blots of crude rat brain extract stained with Fox3/NeuN. It is expressed as two alternate transcripts with apparent SDS-PAGE molecular weight 46 and 48kDa. Protocol on Data-sheet.
Blots of crude rat brain extract stained with Fox3/NeuN. It is expressed as two alternate transcripts with apparent SDS-PAGE molecular weight 46 and 48kDa. Protocol on Data-sheet.