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| Size | List Price | Price | Cart |
|---|---|---|---|
| 150 ul | $456.00 | Add to Cart | |
| 50 ul | $190.00 | Add to Cart |
The acid-sensing ion channel family (ASIC) comprises six discrete ASIC subunits (ASIC 1A, ASIC 1B, ASIC 2A, ASIC 2B, ASIC 3, ASIC 4) that detect tissue acidosis (i.e. a decrease in pH). This acidosis phenomenon is a response to tissue injury, pain and inflammation |
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- Product Publications
Product Publications
- Diego N. Messina, Emanuel D. Peralta, and Cristian G. Acosta. (2023). Complex Alterations in Inflammatory Pain and Analgesic Sensitivity in Young and Ageing Female Rats: Involvement of ASIC3 and Nav1.8 in Primary Sensory Neurons. Research Square. doi: 10.21203/rs.3.rs-3433175/v1
- Hossain, MZ, Ando, H, Unno, S, Nakamoto, T, Kitagawa, J. Functional involvement of acid‐sensing ion channel 3 in the swallowing reflex in rats. Neurogastroenterol Motil. 2019; 00:e13728. https://doi.org/10.1111/nmo.13728
- Nicola Montalbetti, James G Rooney, Allison L. Marciszyn, and Marcelo D. Carattino. (2018) ASIC3 fine-tunes bladder sensory signaling. American Journal of Physiology-Renal Physiology. 21 MAR 2018https://doi.org/10.1152/ajprenal.00630.2017
- Masashi Izumi, Masahiko Ikeuchi, Qinghui Ji, Toshikazu Tani. (2012). Local ASIC3 modulates pain and disease progression in a rat model of osteoarthritis. Journal of Biomedical Science, 19:77 doi: 10.1186/1423-0127-19-77
- Kiyomi Hori, Noriyuki Ozaki, Shigeyuki Suzuki, Yasuo Sugiura. (2010). Upregulations of P2X3 and ASIC3 involve in hyperalgesia induced by cisplatin administration in rats. PAIN 149 (2010) 393–405. doi: 10.1016/j.pain.2010.03.005
- Yoshiyasu Uchiyama, Chin-Chang Cheng, Keith G Danielson, Joji Mochida, Todd J Albert, Irving M Shapiro and and Makarand V Risbud. (2007). Expression of Acid-Sensing Ion Channel 3 (ASIC3) in Nucleus. Pulposus Cells of the Intervertebral Disc Is Regulated by p75NTR and ERK Signaling. JOURNAL OF BONE AND MINERAL RESEARCH. Volume 22, Number 12, doi: 10.1359/JBMR.070805
- R. Ambalavanara, C. Yallampallib, U. Yallampallib and D. Dessema. (2007). Injection of adjuvant but not acidic saline into craniofacial muscle evokes nociceptive behaviors and neuropeptide expression. Neuroscience, doi: 10.1016/j.neuroscience.2007.07.058
- T. Fukuda, H. Ichikawa, R. Terayama, T. Yamaai, T. Kuboki and T. Sugimoto. (2006). ASIC3-immunoreactive neurons in the rat vagal and glossopharyngeal sensory ganglia. Brain Research, doi: 10.1016/j.brainres.2006.01.039
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Images
Detection of ASIC3 expression in normal and CF human lung tissues by immunofluorescence microscopy. Normal (top panels A-C) and CF human lung sections (bottom panels D-F) were labeled with a specific antibody against ASIC3 (green channel) and the DNA-selective Hoechst dye (blue channel). J. Biol. Chem., Vol. 281, Issue 48, 36960-36968, December 1, 2006
Detection of ASIC3 expression in normal and CF human lung tissues by immunofluorescence microscopy. Normal (top panels A-C) and CF human lung sections (bottom panels D-F) were labeled with a specific antibody against ASIC3 (green channel) and the DNA-selective Hoechst dye (blue channel). J. Biol. Chem., Vol. 281, Issue 48, 36960-36968, December 1, 2006
ASIC3 expression compared to other nociceptive ion channels. DRG sections double-labeled for ASIC3 (red) and either P2X3 (green, A) or TRPV1 (green, B); double-labeled cells are yellow or orange. Circle charts show the relative distribution of the three receptors among all DRG neurons. ASIC3 and P2X3 expression overlapped in only 4% of neurons, while some 35% of ASIC3-positive neurons also express TRPV1.
ASIC3 expression compared to other nociceptive ion channels. DRG sections double-labeled for ASIC3 (red) and either P2X3 (green, A) or TRPV1 (green, B); double-labeled cells are yellow or orange. Circle charts show the relative distribution of the three receptors among all DRG neurons. ASIC3 and P2X3 expression overlapped in only 4% of neurons, while some 35% of ASIC3-positive neurons also express TRPV1.
ASIC3 (Dilution 1:10) amd P2X3 (Dilution 1:500) satining of rat Dorsal Root Ganglia (DRGs) of cisplatin-treated animals. After dilution in 0.1 M phosphate-buffered saline (PBS) containing 1.5% normal goat serum and 0.3% Triton X-100 (Sigma), DRG sections were incubated with either guinea pig polyclonal antiserum against synthetic rat ASIC3 and rabbit polyclonal antiserum against synthetic rat P2X3 (1:500; Neuromics).
ASIC3 (Dilution 1:10) amd P2X3 (Dilution 1:500) satining of rat Dorsal Root Ganglia (DRGs) of cisplatin-treated animals. After dilution in 0.1 M phosphate-buffered saline (PBS) containing 1.5% normal goat serum and 0.3% Triton X-100 (Sigma), DRG sections were incubated with either guinea pig polyclonal antiserum against synthetic rat ASIC3 and rabbit polyclonal antiserum against synthetic rat P2X3 (1:500; Neuromics).