Product Details
Catalog Number: GP14100
Applications: IHC
Type: Guinea Pig IgG
Immunogen: YTGSLKPEDAEVFKDSMVPGEK
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Whole serum
Format B: liquid
Species Reactivity: Human, Rat
Entrez: 7442
UniProt: Q8NER1
RRID: AB_1624142
Downloads: Datasheet (pdf)
Product Sizes
| Size | List Price | Price | Cart |
|---|---|---|---|
| 150 ul | $475.00 | Add to Cart | |
| 50 ul | $215.00 | Add to Cart |
ITEM IS CURRENTLY ON BACKORDER - PROJECTED RELEASE 11/27 VR1 (vanilloid receptor 1) is a channel activated by capsaicin, the pungent ingredient in hot peppers. It was isolated from sensory neurons. Sequence analysis suggests that VR1 has six transmembrane domains and intracellular N- and C-termini. It shares structural similarities with the family of putative store-operated calcium channels. VR1 is expressed by nociceptive sensory neurons. It is activated by noxious heat and is thought to function as transducer of noxious thermal stimuli. Product Highlights: |
Supporting Products
| Name | Catalog # | Size |
|---|---|---|
| VR1 C-terminus (TRPV1) | P14100 | 100 ug Blocking Peptide |
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- Product Publications
Product Publications
- Madoka Koyanagi, Ryosuke Ogido, Akari Moriya, Mamiko Saigo, Satoshi Ihida, Tomoko Teranishi, Jiro Kawada, Tatsuya Katsuno, Kazuo Matsubara, Tomohiro Terada, Akira Yamashita, and Satoshi Imai. (2024). Development of a 3-Dimensional Organotypic Model with Characteristics of Peripheral Sensory Nerves. Cell Reports Methods. doi: 10.1016/j.crmeth.2024.100835
- Tomoki Yamaguchi, Siamak Salavatian, Yuki Kuwabara, Abigail Hellman, Bradley K. Taylor, Kimberly Howard-Quijano, and Aman Mahajan. (2023). Thoracic Dorsal Root Ganglion Application of Resiniferatoxin Reduces Myocardial Ischemia-Induced Ventricular Arrhythmias. Biomedicines, 11, 2720. doi: 10.3390/biomedicines11102720
- Erick J. Rodrıguez-Palma, Yarim E. De la Luz-Cuellar, Ana M. Islas-Espinoza, Adalberto E. Felix-Leyva, Stephanie I. Shiers, Guadalupe Garcıa, Jorge E. Torres-Lopez, Rodolfo Delgado-Lezama, Janet Murbartian, Theodore J. Price, and Vinicio Granados-Soto. (2023). Activation of a6-Containing GABAA Receptors Induces Antinociception Under Physiological and Pathological Conditions. Pain, 164(5), 948–966. doi: 10.1097/j.pain.0000000000002763
- Tarek Ibrahim, Ping Wu, Li-Ju Wang, Alexei Tumanov, Zhao Lai, Korri Weldon, Yidong Chen, and Shivani Rupare. (2023). Sex-Dependent Differences in the Genomic Profile of Lingual Sensory Neurons in Naïve and Tongue Tumor Bearing Mice. bioRxiv. doi: 10.1101/2023.01.14.524011
- Kensho Kanehisa, Keisuke Koga, Sho Maejima, Yuto Shiraishi, Konatsu Asai, Miho Shiratori-Hayashi, Mei-Fang Xiao, Hirotaka Sakamoto, Paul F. Worley, and Makoto Tsuda. (2022). Neuronal Pentraxin 2 Is Required for Facilitating Excitatory Synaptic Inputs onto Spinal Neurons Involved in Pruriceptive Transmission in a Model of Chronic Itch. Nature Communications, 13:2367. doi: 10.1038/s41467-022-30089-x
- Judit Rosta, Mate Toth, Nadine Friedrich, Peter Santha, Gabor Jancso, and Maria Dux. (2022). Insulin Sensitizes Neural and Vascular TRPV1 Receptors in the Trigeminovascular System. The Journal of Headache and Pain, 23(7). doi: 10.1186/s10194-021-01380-x
- Abraham B. Beckers, Ellen Wilms, Zlatan Mujagic, Béla Kajtár, Kata Csekő, Zsa Zsa R. M. Weerts, Lisa Vork, Freddy J. Troost, Joanna W. Kruimel, José M. Conchillo, Zsuzsanna Helyes, Ad A. M. Masclee, Daniel Keszthelyi, and Daisy M. A. E. Jonkers. (2021). Age-Related Decrease in Abdominal Pain and Associated Structural- and Functional Mechanisms: An Exploratory Study in Healthy Individuals and Irritable Bowel Syndrome Patients.Frontiers in Pharmacology. doi: 10.3389/fphar.2021.806002
- Xiaodong Yan, Sitao Zhang, Haiyan Zhao, Ping Liu, Haixia Huang, Weizhen Niu, Wei Wang, and Chen Zhang. (2021). ASIC2 Synergizes with TRPV1 in the Mechano-Electrical Transduction of Arterial Baroreceptors. Neuroscience Bulletin. doi: 10.1007/s12264-021-00737-1
- Qing-Tao Meng, Xian-Yu Liu, Xue-Ting Liu, Devin M. Barry, Hua Jin, Yu Sun, Qianyi Yang, Li Wan, Jin-Hua Jin, Kai-Feng Shen, Admire Munanairi, Ray Kim, Jun Yin Ailin Tao, and Zhou-Feng Chen. (2021). BNP Facilitates NMB-Mediated Histaminergic Itch via NPRC-NMBR Crosstalk. bioRxiv. doi: 10.1101/2021.01.26.428310
- Seol-Hee Kim, Parmvir K. Bahia, Mayur Patil, Sydney Sutton, Isobel Sowells, Stephen H. Hadley, Marian Kollarik, and Thomas E. Taylor-Clark. (2020). Development of a Mouse Reporter Strain for the Purinergic P2X2 Receptor. eNeuro. doi: 10.1523/ENEURO.0203-20.2020
- Devin M. Barry, Xue-Ting Liu, Benlong Liu, Xian-Yu Liu, Fang Gao, Xiansi Zeng, Juan Liu, Qianyi Yang, Steven Wilhelm, Jun Yin, Ailin Tao, and Zhou-Feng Chen. (2020). Exploration of Sensory and Spinal Neurons Expressing Gastrin-Releasing Peptide in Itch and Pain Related Behaviors. Nature Communications, 11:1397. doi: 10.1038/s41467-020-15230-y
- Yoshie Umehara, Sumika Toyama, Mitsutoshi Tominaga, Hironori Matsuda, Nobuaki Takahashi, Yayoi Kamata, François Niyonsaba, Hideoki Ogawa, and Kenji Takamori. (2020). Robust Induction of Neural Crest Cells to Derive Peripheral Sensory Neurons from Human Induced Pluripotent Stem Cells. Scientific Reports, 10:4360. doi: 10.1038/s41598-020-60036-z
- Nan-Qi Lia, Yang Tang, Si-Ting Huang, Xue-Ting Liu, Li-Ping Zeng, Hui Li, and Li Wan. (2020). Modulation of NR1 Receptor By CaMKIIα Plays an Important Role in Chronic Itch Development in Mice. Brain Research Medium. doi: 10.1016/j.brainresbull.2020.02.011
- Seol-Hee Kim, Stephen H Hadley, Mikayla Maddison, Mayur Patil, Byeong Cha, Marian Kollarik, and Thomas E Taylor-Clark. (2020). Mapping of Sensory Nerve Subsets Within the Vagal Ganglia and the Brainstem Using Reporter Mice for Pirt, TRPV1, 5HT3, and Tac1 Expression. eNeuro. doi: 10.1523/ENEURO.0494-19.2020
Sho Kato, Hiroki Wakabayashi , Taro Nakagawa, Gaku Miyamura, Yohei Naito, Takahiro Iino, Akihiro Sudo (2019). Teriparatide improves pain-related behavior and prevents bone loss in ovariectomized mice.Journal of Orthopaedic Surgery. https://doi.org/10.1177/2309499019893194
- Shijin Xuab, Yan Xu, Xueying Cheng, Cheng Huang, Yonglu Pan, Shiyun Jin, Wei Xiong, Li Zhang, Shufang He, Ye Zhang. (2019). Inhibition of DRG-TRPV1 upregulation in myocardial ischemia contributes to exogenous cardioprotection. Journal of Molecular and Cellular Cardiology. https://doi.org/10.1016/j.yjmcc.2019.12.003
Dorte X. Gram, Josefine Fribo, Istvan Nagy, Carsten Gotfredsen, Ana Charrua, John B. Hansen, Anker J. Hansen, Arpad Szallasi. (2019). TRPV1 Antagonists as Novel Anti-Diabetic Agents: Regulation of Oral Glucose Tolerance and Insulin Secretion Through Reduction of Low-Grade Inflammation? Medical Sciences, 7, 82. doi: 10.3390/medsci7080082
M. Patil, A.H. Hovhannisyan, A. Wangzhou, J. Mecklenburg, W. Koek, V. Goffin, D. Grattan, U. Boehm, G. Dussor, T.J. Price, A.N. Akopian. (2019). Prolactin Receptor Expression in Mouse Dorsal Root Ganglia Neuronal Subtypes Is Sex-Dependent. Journal of Neuroendocrinology. doi: 10.1111/jne.12759
Silvia Gutierrez, P Abigail Alvarado-Vazquez, James C Eisenach, E Alfonso Romero-Sandoval, and M Danilo Boada. (2019). Tachykinins modulate nociceptive responsiveness and sensitization: In vivo electrical characterization of primary sensory neurons in tachykinin knockout (Tac1 KO) mice. Molecular Pain Volume 15: 1–16. DOI: 10.1177/1744806919845750
- Vicki J Swier, Katherine White, David K Meyerholz, Aude Chefdeville, Rajesh Khanna, Jessica C Sieren, Dawn E Quelle, Jill M Weimer (2019). Validating indicators of CNS disorders in a swine model of neurological disease. bioRxiv 514398; doi: https://doi.org/10.1101/514398
- Taro Nakagawa, Hiroki Wakabayashi, Yohei Naito, Sho Kato, Gaku Miyamura, Takahiro Iino, Akihiro Sudo. (July 4, 2018). The effects of bisphosphonate on pain-related behavior and immunohistochemical analyses in hindlimb-unloaded mice. Journal of Orthopaedic Science. https://doi.org/10.1016/j.jos.2018.06.002.
- Mayur J. Patil, Anahit H. Hovhannisyan, Armen N. Akopian. Characteristics of sensory neuronal groups in CGRP-cre-ER reporter mice: Comparison to Nav1.8-cre, TRPV1-cre and TRPV1-GFP mouse lines. Published: June 4, 2018https://doi.org/10.1371/journal.pone.0198601
- Paulino Barragán-Iglesias, Tzu-Fang Lou, Vandita D. Bhat, Salim Megat, Michael D. Burton, Theodore J. Price & Zachary T. Campbell. (2018). Inhibition of Poly(A)-binding protein with a synthetic RNA mimic reduces pain sensitization in mice. Nature Communications 9, Article number: 10 doi:10.1038/s41467-017-02449-5
- Charles A. Warwick. (2017). The role of complement component C5a in nociceptive sensitization. Theses and Dissertations. University of Iowa
- Noémi Bohonyi, Krisztina Pohóczky, Bálint Szalontai, Anikó Perkecz, Krisztina Kovács, Béla Kajtár, Lajos Orbán, Tamás Varga, Sarolta Szegedi, József Bódis, Zsuzsanna Helyes, Miklós Koppán. (2017). Local upregulation of transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1 ion channels in rectosigmoid deep infiltrating endometriosis. Molecular Pain, doi: 10.1177/1744806917705564
- Chen J, Varga A, Selvarajah S, Jenes A, Dienes B, Sousa-Valente J, Kulik A, Veress G, Brain SD, Baker D, Urban L, Mackie K, Nagy I. (2016). Spatial Distribution of the Cannabinoid Type 1 and Capsaicin Receptors May Contribute to the Complexity of Their Crosstalk. Sci Rep., doi: 10.1038/srep33307
- Sarah Krupp. (2016). Effects of neonatal capsaicin on formalin-induced ATF3 expression in the adult rat. The University of Louisville's Institutional Repository Electronic Theses and Dissertations.
- Obadah N. Austah, Nikita B. Ruparel, Michael A. Henry, Roberto J. Fajardo, James E. Schmitz, & Anibal Diogenes. (2016). Capsaicin-sensitive Innervation Modulates the Development of Apical Periodontitis. Journal of Endodontics, doi: 10.1016/j.joen.2016.06.009
- Elaine D. Por, Jae-Hyek Choi & Brian J. Lund. (2015). Low-Level Blast Exposure Increases Transient Receptor Potential Vanilloid 1 (TRPV1) Expression in the Rat Cornea. Current Eye Research, doi: 10.3109/02713683.2015.1122812
- Mruvil Abooj, Mahendra Bishnoi, Christine A. Bosgraaf and Louis S. Premkumar. (2016). Changes in Spinal Cord Following Inflammatory and Neuropathic Pain and the Effectiveness of Resiniferatoxin. The Open Pain Journal, 9, 1-14. doi: 10.2174/1876386301609010001
- Erin M. Boisvert, Sandra J. Engle, Shawn E. Hallowell, Ping Liu, Zhao-Wen Wang & Xue-Jun Li. (2015). The Specification and Maturation of Nociceptive Neurons from Human Embryonic Stem Cells. Scientific Reports, 5, Article number: 16821. doi: 10.1038/srep16821
- Xue-Long Wang, Bin Tian, Ya Huang, Xiao-Yan Peng, Li-Hua Chen, Jun-Cheng Li & Tong Liu. (2015). Hydrogen sulfide-induced itch requires activation of Cav3.2 T-type calcium channel in mice. Scientific Reports, 5, Article number: 16768. doi: 10.1038/srep16768
- Pourtau L, Heeringa AN, Rovere C, Aubert A, Nahon JL, Miraux S, Konsman JP. (2014). Increased circulating rather than spinal cytokines accompany chronic pain behaviors in experimental bone cancer and arthritis. Neuroimmunology and Neuroinflammation, 1:153-60. doi: 10.4103/2347-8659.143680
- S Kelly, R J Chapman, S Woodhams, D R Sagar, J Turner, J J Burston, C Bullock, K Paton, J Huang, A Wong, D F McWilliams, B N Okine, D A Barrett, G J Hathway, D A Walsh, V Chapman. (2013). Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis pain. Ann Rheum Dis, doi: 10.1136/annrheumdis-2013-203413
- M. Shukla, R. Quirion, W. Ma. (2013). Reduced expression of pain mediators and pain sensitivity in amyloid precursor protein over-expressing CRND8 transgenic mice. Neuroscience, Volume 250, Pages 92–101. doi: 10.1016/j.neuroscience.2013.06.064
- Dustin Green, Shivani Ruparel, Linda Roman, Michael A. Henry, Kenneth M. Hargreaves. (2013). Role of Endogenous TRPV1 Agonists in a Post-Burn Pain Model of Partial-Thickness Injury. PAIN, doi: 10.1016/j.pain.2013.07.040
- Tong Liu, Temugin Berta, Zhen-Zhong Xu, Chul-Kyu Park, Ling Zhang, Ning Lü, Qin Liu, Yang Liu, Yong-Jing Gao, Yen-Chin Liu, Qiufu Ma, Xinzhong Dong, and Ru-Rong Ji. (2012). TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice. J Clin Invest., 122(6): 2195–2207. doi: 10.1172/JCI45414
- Iryna A. Khasabova, Sergey Khasabov, Justin Paz, Catherine Harding-Rose, Donald A. Simone, and Virginia S. Seybold. (2012). Cannabinoid Type-1 Receptor Reduces Pain and Neurotoxicity Produced by Chemotherapy. The Journal of Neuroscience, 32(20): 7091-7101; doi: 10.1523/ JNEUROSCI.0403-12.2012
- Robert P. Watson, Elliot Lilley, Moh Panesar, Gurdip Bhalay, Steven Langridge, Shin-Shay Tian, Conor McClenaghan, Anna Ropenga, Fanning Zeng, Mark S. Nash. (2012). Increased prokineticin 2 expression in gut inflammation: role in visceral pain and intestinal ion transport. Neurogastroenterology & Motility, Volume 24, Issue 1, pages 65–e12. doi: 10.1111/j.1365-2982.2011.01804.x
- Sarah E. Canetta, Edlira Luca, Elyse Pertot, Lorna W. Role, David A. Talmage. (2011). Type III Nrg1 Back Signaling Enhances Functional TRPV1 along Sensory Axons Contributing to Basal and Inflammatory Thermal Pain Sensation. PLoS ONE, 6(9): e25108. doi: 10.1371/journal.pone.0025108
- Mahendra Bishnoi, Christine A Bosgraaf, Mruvil Abooj, Linlin Zhong, Louis S Premkumar. (2011). Streptozotocin-Induced Early Thermal Hyperalgesia is independent of Glycemic State of Rats: Role of Transient Receptor Potential Vanilloid 1(TRPV1) and inflammatory mediators. Molecular Pain, 7:52. doi: 10.1186/1744-8069-7-52
- Mariusz Mucha, Lezanne Ooi, John E. Linley, Pawel Mordaka, Carine Dalle, Brian Robertson, Nikita Gamper, and Ian C. Wood. (2010). Transcriptional Control of KCNQ Channel Genes and the Regulation of Neuronal Excitability.J. Neurosci., 30: 13235 - 13245. doi: 10.1523/JNEUROSCI.1981-10.2010
- James P. Lund,Somayeh Sadeghi,Tuija Athanassiadis, Nadia Caram Salas, François Auclair, Benoît Thivierge, Isabel Arsenault, Pierre Rompré, Karl-Gunnar Westberg, and Arlette Kolta. (2010). Assessment of the Potential Role of Muscle Spindle Mechanoreceptor Afferents in Chronic Muscle Pain in the Rat Masseter Muscle. PLoS One, 5(6): e11131. doi: 10.1371/journal.pone.0011131
- E. Matthew Hoffman, Ruben Schechter, and Kenneth E. Miller. (2010). Fixative Composition Alters Distributions of Immunoreactivity for Glutaminase and Two Markers of Nociceptive Neurons, Nav1.8 and TRPV1, in the Rat Dorsal Root Ganglion. J. Histochem. Cytochem., 58: 329 - 344.
- Hao Sun, De-Pei Li, Shao-Rui Chen, Walter N. Hittelman and Hui-Lin Pan. (2009). Sensing of Blood Pressure Increase by Transient Receptor Potential Vanilloid 1 Receptors on Baroreceptors. The Journal of Pharmacology and Experimental Therapeutics, doi: 10.1124/jpet.109.160473
- Noritaka Imamachi, Goon Ho Park, Hyosang Lee, David J. Anderson, Melvin I. Simon, Allan I. Basbaum, and Sang-Kyou Han. (2009). TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms. PNAS, 106: 11330 - 11335. doi: 10.1073/pnas.0905605106
- Djalil Baiou, Peter Santha, Antonio Avelino, Ana Charrua, Timea Bacskai, Klara Matesz, Francisco Cruz, Istvan Nagy. (2007). Neurochemical characterization of insulin receptor-expressing primary sensory neurons in wild-type and vanilloid type 1 transient receptor potential receptor knockout mice. J. Comp. Neurol., 503 (2), 334-347.
- T. NAKAGAWA, K. WAKAMATSU, N. ZHANG, S. MAEDA, M. MINAMI, M. SATOH AND S. KANEKO. (2007). INTRATHECAL ADMINISTRATION OF ATP PRODUCES LONG-LASTING ALLODYNIA IN RATS: DIFFERENTIAL MECHANISMS IN THE PHASE OF THE INDUCTION AND MAINTENANCE. Neuroscience, 147. 445–455. doi: 10.1016/j.neuroscience.2007.03.045
- Amol M. Patwardhan, Nathaniel A. Jeske, Theodore J. Price, Nikita Gamper, Armen N. Akopian, and Kenneth M. Hargreaves. (2006). The cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin. PNAS, 103: 11393-11398. doi: 10.1073/pnas.0603861103
- Ahluwalia J, Rang H, and Nagy I. (2002). The putative role of vanilloid receptor-like protein-1 in mediating high threshold noxious heat-sensitivity in rat cultured primary sensory neurons. Eur J Neurosci, 16:1483-1489. doi: 10.1046/j.1460-9568.2002.02231.x
- Hong S, and Wiley JW. (2005). Early painful diabetic neuropathy is associated with differential changes in the expression and function of vanilloid receptor 1. J Biol Chem, 280(1):618-27. doi: 10.1074/jbc.M408500200
- Hwang SJ, Burette A, and Valtschanoff JG. (2003). VR1-positive primary afferents contact NK1-positive spinoparabrachial neurons. J Comp Neurol, 460:255-265. doi: 10.1002/cne.10647
- Liu M, Liu MC, Magoulas C, Priestly JV, Willmott NJ. (2003). Versatile Regulation of Cytosolic Ca2+ by Vanilloid Receptor I in Rat Dorsal Root Ganglion Neurons. J Biol Chem, 278(7): 5462-5472. doi: 10.1074/jbc.M209111200
- Price T, Louria M, Candelario-Soto D, Dussor G, Jeske N, Patwardhan A, Diogenes A, Trott A, Hargreaves K and Flores C. (2005). Treatment of trigeminal ganglion neurons in vitro with NGF, GDNF or BDNF: effects on neuronal survival, neurochemical properties and TRPV1-mediated neuropeptide secretion. BMC Neurosci, 6:4. doi: 10.1186/1471-2202-6-4
- Wadachi R and Hargreaves KM. (2006). Trigeminal Nociceptors Express TLR-4 and CD14: a Mechanism for Pain due to Infection. J Dent Res, 85(1):49-53.
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Images
TRPV1 staining of mouse inferior olive using Cy3-conjugated donkey anti-guinea pig secondary antibodies (red color) and DAPI (blue) as a nuclear counterstain.
TRPV1 staining of mouse inferior olive using Cy3-conjugated donkey anti-guinea pig secondary antibodies (red color) and DAPI (blue) as a nuclear counterstain.
VR1-C staining of rat dorsal horn (dilution 1:100).
VR1-C staining of rat dorsal horn (dilution 1:100).
(J Dent Res 85(1):49-53, 2006) : Evaluation of the expression patterns of TLR4 and CD14 in trigeminal sensory neurons. White arrows depict examples of neurons expressing both markers for each row of three images, and yellow arrows depict examples of neurons that express one but not both markers.
(J Dent Res 85(1):49-53, 2006) : Evaluation of the expression patterns of TLR4 and CD14 in trigeminal sensory neurons. White arrows depict examples of neurons expressing both markers for each row of three images, and yellow arrows depict examples of neurons that express one but not both markers.