Product Details
This product is no longer available - Contact david@neuromics.com with any questions Human Myelin Protein Zero (Po) is a 28400 dalton protein (258 amino acids) found in myelin of the PNS. Expressed in myelinating Schwann cells, Po serves as a homophilic adhesion molecule, allowing adjacent laminae of the myelin sheath to undergo compaction. Po is also a marker of a subpopulation of neural crest cells. Mutations of the MPZ gene product in humans is responsible for Charcot-Marie-Tooth type 1B neuropathies (HMSN1B). |
Images
(a tissue section through an adult sciatic nerve), Po (green staining) can be seen in the myelin and Schwann cell processes surrounding the nodes of Ranvier. In this photomicrograph, rabbit antibodies against LAMP (lysozome-associated membrane glycoprotein) (red staining) serves as the counterstain, and DAPI (blue staining) allows visualization of nuclei.
Micrographs depicting SSeCKS colocalization with myelination markers (CNPase and Pzero). rmen et al. Journal of Brachial Plexus and Peripheral Nerve Injury 2008 3:8 doi:10.1186/1749-7221-3-8.
Human Schwann Cells (cat no. HMP303) stained with P0 (CH23009, green fluorescence) + DAPI (blue) counterstain.