Product Details
Catalog Number: GP10110
Applications: IHC
Type: Guinea Pig IgG
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Mouse, Rat
Entrez: 5173
UniProt: P01213
RRID: AB_2162536
Downloads: Datasheet (pdf)
Product Sizes
| Size | List Price | Price | Cart |
|---|---|---|---|
| 150 ul | $475.00 | Add to Cart | |
| 50 ul | $220.00 | Add to Cart |
Dynorphin peptides are members of the opioid peptide family and contain the canonical opioid sequence Tyr-Gly-Gly-Phe. These peptides are derived from prodynorphin and include dynorphin A, dynorphin B and alpha neo-endorphin. Of the opioid peptides, the dynorphins have the highest affinity for the kappa opioid receptor. They are found distributed throughout the nervous system and play a role in many physiological functions. |
Supporting Products
| Name | Catalog # | Size |
|---|---|---|
| proDynorphin | P10116 | 100 ug Blocking Peptide |
- Product ReviewsEverything went smoothly! Product Name: proDynorphin (rat), Guinea Pig – (Cat# GP10110) http://bit.ly/Sw4RJ9 Organization: University of Texas - Austinsimone - Jan 27, 2017 - Rating: 5.0Product shipped timely and in secured conditions to ensure antibody viability. We are currently optimizing a protocol with their guinea pig anti-prodynorphin primary antibody. I am happy to revisit Neuromics for future research needs. Product Name: proDynorphin (rat), Guinea Pig – (Cat# GP10110) http://bit.ly/Sw4RJ9 Organization: Temple UniversitySteven J Simmons - Feb 05, 2016 - Rating: 5.0Very nice antibody and ordering is very easy usin the website. Product Name: proDynorphin (rat), Guinea Pig – (Cat# GP10110) http://bit.ly/Sw4RJ9 Organization: Rosalind Franklin UniversityGina Dejoseph - Oct 07, 2015 - Rating: 5.0Good order service. Quick delivery. Easy order from website. Product Name: proDynorphin (rat), Guinea Pig – (Cat# GP10110) http://bit.ly/Sw4RJ9 Organization: OHSURubing Xing - Oct 02, 2015 - Rating: 5.0We had good experience with your company Product Name: proDynorphin (rat), Guinea Pig – (Cat# GP10110) http://bit.ly/Sw4RJ9 Organization: NIH/NIDAHui - Jul 25, 2014 - Rating: 5.0
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- Product Publications
Product Publications
- Juan Miguel Jimenez-Andrade Martha B. Ramírez-Rosas, Sun Hee Park, Renee Parker, Matthew R. Eber, Rebecca Cain, Mary Newland, Fang-Chi Hsu, Carol A. Kittel, Thomas J. Martin, Enriqueta Muñoz-Islas, Yusuke Shiozawa, and Christopher M. Peters. (2023). Evaluation of Pain Related Behaviors and Disease Related Outcomes in an Immunocompetent Mouse Model of Prostate Cancer Induced Bone Pain. Journal of Bone Oncology, 100510. doi: 10.1016/j.jbo.2023.100510
- Marie-Eve Di Raddo, Marija Milenkovic, Meenalochani Sivasubramanian, Ahmed Hasbi, Jack Bergman, Sarah Withey, Bertha K. Madras, and Susan R. George. (2023). Delta 9-Tetrahydrocannabinol Does Not Upregulate an Aversive Dopamine Receptor Mechanism in Adolescent Brain Unlike in Adults. Current Research in Neurobiology, 100107. doi: 10.1016/j.crneur.2023.100107
- Chong guang Chen, Melanie Widmann, Christoph Schwarzer, and Lee-Yuan Liu-Chen. (2021). Considerations on Using Antibodies for Studying the Dynorphins/Kappa Opioid Receptor System. Handbook of Experimental Pharmacology. doi: 10.1007/164_2021_467
- Ellen P. S. Conceicao, Christian Reynolds, Shaun F. Morrison, and Christopher J. Madden. (2021). Activation of Transient Receptor Potential Vanilloid 1 Channels in the Nucleus of the Solitary Tract and Activation of Dynorphin Input to the Median Preoptic Nucleus Contribute to Impaired BAT Thermogenesis in Diet Induced Obesity. eNeuro. doi: 10.1523/ENEURO.0048-21.2021
- Xinwen Dong, Sa Li, and Gilbert J. Kirouac. (2020). A Projection from the Paraventricular Nucleus of the Thalamus to the Shell of the Nucleus Accumbens Contributes to Footshock Stress-Induced Social Avoidance. Neurobiology of Stress. doi: 10.1016/j.ynstr.2020.100266
- Matthew B. Pomrenze, Simone M. Giovanetti, Rajani Maiya, Adam G. Gordon, Lauren J. Kreeger, Robert O. Messing. (2019). Dissecting the Roles of GABA and Neuropeptides from Rat Central Amygdala CRF Neurons in Anxiety and Fear Learning. Cell Reports. Volume 29, Issue 1, 1 October 2019, Pages 13-21.e4. https://doi.org/10.1016/j.celrep.2019.08.083
- Alexandra S Agostinho, Mario Mietzsch, Luca Zangrandi, Iwona Kmiec, Anna Mutti, Larissa Kraus, Pawel Fidzinski, Ulf C Schneider, Martin Holtkamp, Regine Heilbronn, Christoph Schwarzer (2019). Dynorphin‐based “release on demand” gene therapy for drug‐resistant temporal lobe epilepsy. EMBO Mol Med e9963 https://doi.org/10.15252/emmm.201809963
- S. Garcia-Cerro, S. Mas, A. Gortat, C. Sindreu, A. Martinez-Pinteno, F. Marmol, D. Boloc, N. Rodriguez, P. Gasso, A. Lafuente. (2018). Different Modulation of Rps6 Phosphorylation by Risperidone in Striatal Cells Sub Populations: Involvement of the mTOR Pathway in Antipsychotic-Induced Extrapyramidal Symptoms in Mice. Neuropsychiatry, Vol. 8, Issue 3. doi: 10.4172/neuropsychiatry.1000436
- T.A. Retson, E.J. Van Bockstaele. (2013). Coordinate regulation of noradrenergic and serotonergic brain regions by amygdalar neurons. Journal of Chemical Neuroanatomy. Journal of Chemical Neuoanatomy, doi: 10.1016/j.jchemneu.2013.04.003
- M. Luisa Laorden, Szilamér Ferenczi, Bernadett Pintér-Kübler, Laura L. González-Martín, M. Carmen Lasheras, Krisztina J. Kovács, M. Victoria Milanés, Cristina Núñez. (2012). Hypothalamic Orexin-A Neurons Are Involved in the Response of the Brain Stress System to Morphine Withdrawal. PLoS ONE, doi: 10.1371/journal.pone.0036871
- B.A.S. Reyes, A.F. Carvalho, K. Vakharia. and E.J. Van Bockstaele. (2011). Amygdalar peptidergic circuits regulating noradrenergic locus coeruleus neurons: Linking limbic and arousal centers. Experimental Neurology, doi: 10.1016/j.expneurol.2011.04.001
- Wulf Haubensak, Prabhat S. Kunwar, Haijiang Cai1, Stephane Ciocchi, Nicholas R. Wall, Ravikumar Ponnusamy, Jonathan Biag, Hong-Wei Dong, Karl Deisseroth, Edward M. Callaway, Michael S. Fanselow, Andreas Lüthi & David J. Anderson. (2010). Genetic dissection of an amygdala microcircuit that gates conditioned fear. Nature, 468, 270-276. doi: 10.1038/nature09553
- Melissa L. Perreault, Ahmed Hasbi, Mohammed Alijaniaram, Theresa Fan, George Varghese, Paul J. Fletcher, Philip Seeman, Brian F. O'Dowd, and Susan R. George. (2010). The Dopamine D1-D2 Receptor Heteromer Localizes in Dynorphin/Enkephalin Neurons: INCREASED HIGH AFFINITY STATE FOLLOWING AMPHETAMINE AND IN SCHIZOPHRENIA. J. Biol. Chem., 285: 36625 - 36634. doi: 10.1074/jbc.M110.159954
- Cristina Núñez, Fátima Martín, Anna Földes, M. Luisa Laorden, Krisztina J. Kovács, M. Victoria Milanés. (2010). Induction of FosB/ΔFosB in the brain stress system-related structures during morphine dependence and withdrawal. Journal of Neurochemistry, doi: 10.1111/j.1471-4159.2010.06765.x
- N. Maolood and B. Meister. (2009). Nociceptin/Orphanin FQ Peptide in Hypothalamic Neurones Associated with the Control of Feeding Behaviour. Journal of Neuroendocrinology, Volume 22 Issue 2, Pages 75 - 82. doi: 10.1111/j.1365-2826.2009.01946.x
- Chris Lough, Tracey Young, Renee Parker, Shannon Wittenauer and Michelle Vincler. (2007). Increased spinal dynorphin contributes to chronic nicotine-induced mechanical hypersensitivity in the rat. Neuroscience Letters, doi: 10.1016/j.neulet.2007.06.002
- Kyle G. Halvorson, BA, Molly A. Sevcik, BA, Joseph R. Ghilardi, BS, BA, Lucy J. Sullivan, BA, Nathan J. Koewler, BS, Frieder Bauss, PhD, and Patrick W. Mantyh, PhD. (2008). Intravenous Ibandronate Rapidly Reduces Pain, Neurochemical Indices of Central Sensitization, Tumor Burden, and Skeletal Destruction in a Mouse Model of Bone Cancer. J Pain Symptom Manage, doi: 10.1016/j.jpainsymman.2007.10.005
- Xiaying Zhua, Michelle A. Vincler, Renee Parker and James C. Eisenach. (2006). Spinal cord dynorphin expression increases, but does not drive microglial prostaglandin production or mechanical hypersensitivity after incisional surgery in rats. PAIN, doi: 10.1016/j.pain.2006.04.027
- Gardell LR, Wang R, Ehrenfels C, Ossipov MH, Rossimando AJ, Miller S, Buckley C, Cai AK, Tse A, Foley SF, Gong B, Walua L, Carmillo P, Worley D, Huang C, Engbeer T, Pepinsky B, Cate RL, Vanderah TW, Lai J, Sah DWY, Porreca F. (2003). Multiple actions of systemic artemin in experimental neuropathy. Nature, Med. 9: 1383-1389. doi: 10.1038/nm944
- Sabino MC, Ghilardi JR, Jongen JLM, Keyser CP, Luger NM, Mach DB, Peters CM, Rogers SD, Schwei MJ, de Felipe C, Mantyh PW. (2002). Simultaneous Reduction in Cancer Pain, Bone Destruction, and Tumor Growth by Selective Inhibition of Cyclooxygenase-2. Cancer Resear., 62:7343-7349.
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Images
Systemic artemin normalized immunohistochemical markers in the ipsilateral L5 DRG, dorsal spinal cords and sciatic nerves of SNL rats.Immunofluorescent labeling was done 14 d after sham or SNL surgery and treatment with vehicle or artemin starting on day 3 after surgery. Scale bar = 100 um for DRG (first two rows), 50 mum for sciatic nerve (third row) and 200 mum for spinal cord (bottom row). Nature Medicine 9, 1383 - 1389
Systemic artemin normalized immunohistochemical markers in the ipsilateral L5 DRG, dorsal spinal cords and sciatic nerves of SNL rats.Immunofluorescent labeling was done 14 d after sham or SNL surgery and treatment with vehicle or artemin starting on day 3 after surgery. Scale bar = 100 um for DRG (first two rows), 50 mum for sciatic nerve (third row) and 200 mum for spinal cord (bottom row). Nature Medicine 9, 1383 - 1389
Dr Patrick Mantyh et al have successfully used this antibody to stain mouse spinal cord tissue. see J Pain Symptom Manage. 2008 September; 36(3): 289–303.
Dr Patrick Mantyh et al have successfully used this antibody to stain mouse spinal cord tissue. see J Pain Symptom Manage. 2008 September; 36(3): 289–303.
Immuofluorescent detection of Prodynorphin (seen as immunoreactive varicosities) in art hypothalamus (red fluorescence).
Immuofluorescent detection of Prodynorphin (seen as immunoreactive varicosities) in art hypothalamus (red fluorescence).