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This product is no longer available - Contact david@neuromics.com with any questions Human Myelin Protein Zero (Po) is a 28400 dalton protein (258 amino acids) found in myelin of the PNS. Expressed in myelinating Schwann cells, Po serves as a homophilic adhesion molecule, allowing adjacent laminae of the myelin sheath to undergo compaction. Po is also a marker of a subpopulation of neural crest cells. Mutations of the MPZ gene product in humans is responsible for Charcot-Marie-Tooth type 1B neuropathies (HMSN1B). |
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Product Publications
- Jose M. Bermudez-Munoz, Adelaida M. Celaya, Sara Hijazo-Pechero, Jing Wang, Manuel Serrano, and Isabel Varela-Nieto. (2020). G6PD Overexpression Protects from Oxidative Stress and Age Related Hearing Loss. Aging Cell. doi: 10.1111/acel.13275
- David F Russell, Desmon E Rogers, Lilia L Neiman (2019). Nonbinary branching of myelinated dendrites at nodal networks on afferent terminal arbors in paddlefish electroreceptors. Matters. DOI: 10.19185/matters.201812000003
- Wiebke Kallenborn-Gerhardt, Katrin Schröder, Domenico Del Turco, Ruirui Lu, Katharina Kynast, Judith Kosowski, Ellen Niederberger, Ajay M. Shah, Ralf P. Brandes, Gerd Geisslinger, and Achim Schmidtko. (2012). NADPH Oxidase-4 Maintains Neuropathic Pain after Peripheral Nerve Injury. The Journal of Neuroscience, 32(30): 10136-10145; doi: 10.1523/ JNEUROSCI.6227-11.2012
- Silvia Murillo-Cuesta, Guadalupe Camarero, Águeda González-Rodríguez, Lourdes Rodríguez-de la Rosa, Deborah J Burks, Carlos Avendaño, Ángela M Valverde and Isabel Varela-Nieto. (2011). Insulin Receptor Substrate 2 (IRS2)-Deficient Mice Show Sensorineural Hearing Loss That Is Delayed by Concomitant Protein Tyrosine Phosphatase 1B (PTP1B) Loss of Function. Molecular Medicine, doi: 10.2119/molmed.2011.00328
- Christopher P Irmen, Sandra M Siegel and Patrick A Carr. (2008). Localization of SSeCKS in unmyelinated primary sensory neurons. Journal of Brachial Plexus and Peripheral Nerve Injury 2008, 3:8, doi: 10.1186/1749-7221-3-8
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Images
(a tissue section through an adult sciatic nerve), Po (green staining) can be seen in the myelin and Schwann cell processes surrounding the nodes of Ranvier. In this photomicrograph, rabbit antibodies against LAMP (lysozome-associated membrane glycoprotein) (red staining) serves as the counterstain, and DAPI (blue staining) allows visualization of nuclei.
(a tissue section through an adult sciatic nerve), Po (green staining) can be seen in the myelin and Schwann cell processes surrounding the nodes of Ranvier. In this photomicrograph, rabbit antibodies against LAMP (lysozome-associated membrane glycoprotein) (red staining) serves as the counterstain, and DAPI (blue staining) allows visualization of nuclei.
Micrographs depicting SSeCKS colocalization with myelination markers (CNPase and Pzero). rmen et al. Journal of Brachial Plexus and Peripheral Nerve Injury 2008 3:8 doi:10.1186/1749-7221-3-8.
Micrographs depicting SSeCKS colocalization with myelination markers (CNPase and Pzero). rmen et al. Journal of Brachial Plexus and Peripheral Nerve Injury 2008 3:8 doi:10.1186/1749-7221-3-8.
Human Schwann Cells (cat no. HMP303) stained with P0 (CH23009, green fluorescence) + DAPI (blue) counterstain.
Human Schwann Cells (cat no. HMP303) stained with P0 (CH23009, green fluorescence) + DAPI (blue) counterstain.