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| Size | List Price | Price | Cart |
|---|---|---|---|
| 100 ul | $379.00 | Add to Cart |
Using anti-Yo antibodies, three genes have been cloned (CDR 1-3). CDR2 Cerebellar degeneration related protein 2) suppresses the transcriptional activity and DNA binding of nuclear factor-kappa B by an unknown mechanism. The neuron specific expression of CDR2 is regulated by a post-transcriptional mechanism. CDR2 is an onconeuronal antigen; i.e. an antigen that is expressed by systemic tumors and elicits an immune response that may develop into an autoimmune neuronal degeneration. Paraneoplastic cerebellar degeneration (PCD) is a disorder in which breast or ovarian tumors express CDR2, which normally is expressed in cerebellar Purkinje neurons. |
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Images
CDR2 staining of Purkinje neurons in the Human cerebellum
CDR2 staining of Purkinje neurons in the Human cerebellum
Detection of CDR2 in HeLa whole cell lysates.
Detection of CDR2 in HeLa whole cell lysates.