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| Size | List Price | Price | Cart |
|---|---|---|---|
| 100 ul | $425.00 | Add to Cart |
c-Jun is a component of the transcription factor AP-1, which binds and activates transcription at TRE/AP-1 elements. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73 (1,2). Extracellular signals including growth factors, transforming oncoproteins and UV irradiation stimulate phosphorylation of c-Jun at Ser63/73 and activate c-Jun-dependent transcription. Mutation of Ser63/73 renders c-Jun nonresponsive to mitogenic and stress-induced signaling pathways. The MAP kinase homologue SAPK/JNK binds to the amino-terminal region of c-Jun and phosphorylates c-Jun at Ser63/73. In addition, the activity of SAPK/JNK is stimulated by the same signals that activate c-Jun (3,4). c-Jun also plays a role in Neuropathic Pain. |
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Images
Confocal immunofluorescent analysis of HeLa cells.
Confocal immunofluorescent analysis of HeLa cells.
Western blot analysis of extracts from NIH/3T3 and SK-N-MC cells, untreated or UV-treated.
Western blot analysis of extracts from NIH/3T3 and SK-N-MC cells, untreated or UV-treated.
Paraffin-embedded human astrocytoma showing staining for c-Jun. Data courtesy of Cell Signaling Technology, Inc..
Paraffin-embedded human astrocytoma showing staining for c-Jun. Data courtesy of Cell Signaling Technology, Inc..