IL-3 Rat

Interleukin-3 is a pleiotropic cytokine produced primarily by activated T cells. IL-3 is thought to function via specific cell surface receptors to stimulate the proliferation, differentiation and survival of haematopoietic cell lines. IL-3 has also been shown to affect the functional activity of a variety of other cell types including mast cells, eosinophils, megakaryocytes and basophils.
Interleukin-3 Rat Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 140 amino acids and having a molecular mass of 15783 Dalton.
The IL-3 is purified by proprietary chromatographic techniques.

References:

1. Interaction of interleukin-7 and interleukin-3 with the CXCL12-induced proliferation of B-cell progenitor acute lymphoblastic leukemia.  Haematologica 2007 Apr;92(4):450-9.
2. Interleukin 3 and schizophrenia: the impact of sex and family history.  Mol Psychiatry 2007 Mar;12(3):273-82.
3. Transcription factors mediating interleukin-3 survival signals.  Vitam Horm 2006;74:147-63.
4. Tetracycline-regulated intratumoral expression of interleukin-3 enhances the efficacy of radiation therapy for murine prostate cancer.  Cancer Gene Ther 2006 Dec;13(12):1082-92.
5. High levels of neopterin and interleukin-3 in sickle cell disease pa tients.  J Clin Lab Anal 2006;20(3):75-9.
6. Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma.  Blood 2006 Sep 1;108(5):1461-8.