PDGF - AB Human

The term ‘PDGF’ refers to a family of disulphide bond-linked dimeric isoforms that act as autocrine and paracrine growth factors and are produced by a variety of cell types other than platelets.They act as potent mitogens for almost all mesenchymally-derived cells.

Aberrant expression is involved in certain cancers, fibroproliferative disorders and atherosclerosis. The protein also contributes to wound healing and neural regeneration. There are four members of the PDGF family – PDGF A, PDGF B, PDGF C and PDGF D. Two distinct types of PDGF-A exist – a short form that is soluble and a long form that is retained by the extracellular matrix..

 References:

1. Effects of hyperbaric oxygen and platelet derived growth factor on medial collateral ligament fibroblasts.  Undersea Hyperb Med 2007 May-Jun;34(3):181-90.
2. Starch-based microparticles as vehicles for the delivery of active platelet-derived growth factor.  Tissue Eng 2007 Jun;13(6):1259-68.
3. Correlation between platelet-derived growth factor B chain and bone resorption in rat periapical lesions.  J Endod 2007 Jun;33(6):709-11.
4. Hepatic stellate cell protrusions couple platelet-derived growth factor-BB to chemotaxis.  Hepatology 2007 Jun;45(6):1446-53.
5. Prognostic value of platelet-derived growth factor in patients with severe sepsis.  Growth Factors 2007 Feb;25(1):15-24.
6. Endothelin 1, its endothelin type A receptor, connective tissue growth factor, platelet-derived growth factor, and adrenomedullin expression in lungs of pulmonary hypertensive and nonhypertensive chickens.  Poult Sci 2007 May;86(5):909-16.