FGF-2, basic

Basic fibroblast growth factor is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Three alternatively spliced variants encoding different isoforms have been described. The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors.

References:

1. Tracheal cartilage regeneration by slow release of basic fibroblast growth factor from a gelatin sponge.  J Thorac Cardiovasc Surg 2007 Jul;134(1):170-5
2. Tissue regeneration observed in a basic fibroblast growth factor-loaded porous acellular bovine pericardium populated with mesenchymal stem cells. J Thorac Cardiovasc Surg 2007 Jul;134(1):65-73, 73.e1-4
3. The emerging role of the fibroblast growth factor-23-klotho axis in renal regulation of phosphate homeostasis. J Endocrinol 2007 Jul;194(1):1-10
4. Prolonged protective effect of basic fibroblast growth factor-impregnated nanoparticles in royal college of surgeons rats. Invest Ophthalmol Vis Sci 2007 Jul;48(7):3381-7
5. Effect of basic fibroblast growth factor, trafermin, on entero-related fistulae, report of two cases.  Hepatogastroenterology 2007 Apr-May;54(75):803-5
6. Segment boundaries of the adult rat epididymis limit interstitial signaling by potential paracrine factors and segments lose differential gene expression after efferent duct ligation.  Asian J Androl 2007 Jul;9(4):565-73