Product Details
Catalog Number: NI35750
Applications: Transfection Reagent
Type: Cationic Lipid
Storage: Store at 2°C-8°C
Shipping: Ambient
i-FectTM is a novel cationic lipid formulation specifically designed for efficient delivery of siRNAs (small interfering RNAs) into a wide variety of cell types. Customers have been using i-Fect for both in vitro and in vivo applications. Kit Contents
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- Product Publications
Product Publications
- Dylan W Maixner, David Christy, Lingwei Kong, Viacheslav Viatchenko-Karpinski, Kristen A Horner, Shelley B Hooks, and Han-Rong Weng. (2022). Phytohormone Abscisic Acid Ameliorates Neuropathic Pain via Regulating LANCL2 Protein Abundance and Glial Activation at the Spinal Cord. Molecular Pain, 18:17448069221107781. doi: 10.1177/17448069221107781
- Harish R. Krishnan, Huaibo Zhang, Ying Chen, John Peyton Bohnsack, Annie W. Shieh, Handojo Kusumo, Jenny Drnevich, Chunyu Liu, Dennis R. Grayson, Mark Maienschein-Cline, and Subhash C. Pandey. (2022). Unraveling the Epigenomic and Transcriptomic Interplay During Alcohol-Induced Anxiolysis. Molecular Psychiatry. doi: 10.1038/s41380-022-01732-2
- Xu Han, Yawen Zhang, Allen Lee, Zhaoshen Li, Jun Gao, Xiaoyin Wu, Jiulong Zhao, Hui Wang, Di Chen, Duowu Zou, and Chung Owyang. (2021). Upregulation of Acid Sensing Ion Channels is Associated with Esophageal Hypersensitivity in GERD. The FASEB Journal. doi: 10.1096/fj.202100606R
- Angela L. Asirvatham, Charles M. Schworer, Rick Stahl, Deborah Heitzman, and David J. Carey. (2021). Role of A-Kinase Anchoring Proteins in Cyclic-AMP-Mediated Schwann Cell Proliferation. Cellular Signalling. doi: 10.1016/j.cellsig.2021.109977
- Gintautas Grabauskas, Xiaoyin Wu, ShiYi Zhou, JiYao Li, Jun Gao, and Chung Owyang. (2019). High-fat diet–induced vagal afferent dysfunction via upregulation of 2-pore domain potassium TRESK channel. JCI Insight. https://doi.org/10.1172/jci.insight.130402.
- Sumita Chakrabarti, Nai‐Jiang Liu, and Alan R Gintzler. (2019). Phosphorylation of unique C‐terminal sites of the mu‐opioid receptor variants 1B2 and 1C1 influences their Gs association following chronic morphine. Journal of Neurochemistry. https://doi.org/10.1111/jnc.14863
- Taylor Ludman and Ohannes K Melemedjian. (2019). Bortezomib and metformin opposingly regulate the expression of hypoxia-inducible factor alpha and the consequent development of chemotherapy-induced painful peripheral neuropathy. Molecular Pain. doi: 10.1177/1744806919850043
- Taylor Ludman and Ohannes K. Melemedjian. (2019). Bortezomib-induced aerobic glycolysis contributes to chemotherapy-induced painful peripheral neuropathy. Molecular Pain. https://doi.org/10.1177/1744806919837429
- Christopher R. Donnelly. (2018) Neurotrophic Factor Signaling Mechanisms Underlying the Development of Peripheral Neural Circuits (Doctoral Dissertation) University of Michigan
- Tanaka, Takashi; Shimizu, Shoko; Ueno, Masaki; Fujihara, Yoshitaka; Ikawa, Masahito; Miyata, Shingo. MARCKSL1 Regulates Spine Formation in the Amygdala and Controls the Hypothalamic-Pituitary-Adrenal Axis and Anxiety-Like Behaviors. https://doi.org/10.1016/j.ebiom.2018.03.018
- Ana Lis Moyano, Jeffrey Steplowski, Haibo Wang, Kyung-No Son, Diana I. Rapolti, Jeffrey Marshall, Vince Elackattu, Michael S. Marshall, Amy K. Hebert, Cory Reiter, Viviana Ulloa, Katarzyna C. Pituch, Maria I. Givogri, Q.Richard Lu, Howard L. Lipton, Ernesto R. Bongarzone. (2018). microRNA-219 reduces viral load and pathologic changes in Theiler’s virus-induced demyelinating disease. Molecular Therapy. DOI: http://dx.doi.org/10.1016/j.ymthe.2018.01.008
- Ying-jun Liu, Xiao-xi Lin, Jian-qiao Fang, and Fang Fang. Involvement of MrgprC in electroacupuncture analgesia for attenuating CFA-induced thermal hyperalgesia by suppressing the TRPV1 pathway. Pre-pub-full text PDF
- Zhi-Ling Guo, Liang-Wu Fu, Hou-Fen Su, Stephanie C. Tjen-A-Looi, and John C. Longhurst. Role of TRPV1 in acupuncture modulation of reflex excitatory cardiovascular responses. 3 JAN 2018https://doi.org/10.1152/ajpregu.00405.2017
- Rui Li, Li-guo Wang, Qi Wang, Zhi-hua Li, Ya-li Ma, Qing-Duo Guo. (2017). Silencing of IRF3 alleviates chronic neuropathic pain following chronic constriction injury. Biomedicine & Pharmacotherapy, doi: 10.1016/j.biopha.2017.01.085.
- M. Leinders, b, N. Üçeyler, R.A. Pritchard, C. Sommer, L.S. Sorkin. (2016). Increased miR-132-3p expression is associated with chronic neuropathic pain. Experimental Neurology, Volume 283, Part A, Pages 276–286, doi: 10.1016/j.expneurol.2016.06.025
- C.R. Lin, J.K. Cheng,C.H. Wu,K.H. Chen,C.K. Liu. (2016). Epigenetic suppression of potassium-chloride co-transporter 2 expression in inflammatory pain induced by complete Freund's adjuvant (CFA). European Journal of Pain, doi: 10.1002/ejp.925.
- Melissa T. Manners, Adam Ertel, Yuzhen Tian and Seena K. Ajit. (2016). Genome-wide redistribution of MeCP2 in dorsal root ganglia after peripheral nerve injury. Epigenetics & Chromatin, 20169:23. doi: 10.1186/s13072-016-0073-5
- Xiaobo Yanga, Heling Chua,Yuping Tanga,& Qiang Donga. (2016). The role of connexin43 in hemorrhagic transformation after thrombolysis in vivo and in vitro. Neuroscience. doi:10.1016/j.neuroscience.2016.04.040
- Figueroa Johnny D., Serrano-Illan Miguel, Licero Jenniffer, Cordero Kathia, Miranda Jorge D., and De Leon Marino. (2016). Fatty Acid Binding Protein 5 Modulates Docosahexaenoic Acid-Induced Recovery in Rats Undergoing Spinal Cord Injury. Journal of Neurotrauma. doi: 10.1089/neu.2015.4186.
- Yuhao Zhang, Shao-Rui Chen, Geoffroy Laumet, Hong Chen and Hui-Lin Pan. (2016). Nerve Injury Diminishes Opioid Analgesia through Lysine Methyltransferase-Mediated Transcriptional Repression of µ-Opioid Receptors in Primary Sensory Neurons. Journal of Biological Chemistry, doi: 10.1074/jbc.M115.711812.
- Liuming Jiang, Qun Wu, Tao Yang. (2016). Silencing of Id2 Alleviates Chronic Neuropathic Pain Following Chronic Constriction Injury. Journal of Molecular Neuroscience, pp 1-7. doi: 10.1007/s12031-016-0713-z
- Geoffroy Laumet, Judit Garriga, Shao-Rui Chen, Yuhao Zhang, De-Pei Li, Trevor M Smith, Yingchun Dong, Jaroslav Jelinek, Matteo Cesaroni, Jean-Pierre Issa & Hui-Lin Pan. (2015). G9a is essential for epigenetic silencing of K+channel genes in acute-to-chronic pain transition. Nature Neuroscience, doi:10.1038/nn.4165.
- Byung Moon Choi, Soo Han Lee, Sang Mee An, Do Yang Park, Gwan Woo Lee, and Gyu-Jeong Noh. (2015). The time-course and RNA interference of TNF-α, IL-6, and IL-1β expression on neuropathic pain induced by L5 spinal nerve transection in rats. Korean J Anesthesiol. 2015 Apr;68(2):159-169. doi: 10.4097/kjae.2015.68.2.159
- Ziyi Zhoua, Xiaobai Weib, Jun Xiang, Junpeng Gao, Lixin Wang, Jinsong You, Yefeng Cai , Dingfang Caid. (2015). Protection of erythropoietin against ischemic neurovascular unit injuries through the effects of connexin43. Biochemical and Biophysical Research Communications. doi:10.1016/j.bbrc.2015.02.
- Y. Xiang, T. Liu, H. Yang, F. Gao, H. Xiang, A. Manyande, Y. Tian and X. Tian. (2014). NRG1-ErbB signalling promotes microglia activation contributing to incision-induced mechanical allodynia. European Journal of Pain, doi: 10.1002/ejp.590.
- Guo Weizao, Liu Huichen, Li Lin, Yang Man and Du Aihua. (2014). Regulation of lovastatin on a key inflammation-related microRNA in myocardial cells. Chinese Medical Journal, 2014;127(16):2977-2981; doi: 10.3760/cma.j.issn.0366-6999.20140780
- J. H. Winston, Q. Li, S. K. Sarna. (2013). Chronic prenatal stress epigenetically modifies spinal cord BDNF expression to induce sex-specific visceral hypersensitivity in offspring. Article first published online: 4 MAR 2014. Neurogastroenterology & Motility. doi: 10.1111/nmo.12326.
- 15. Tiphaine Dolique, Alexandre Favereaux, Olivier Roca-Lapirot, Virginie Roques, Claire Léger, Marc Landy, Frédéric Nagy. (2013). Unexpected association of the “inhibitory” Neuroligin 2 with excitatory PSD95 in neuropathic pain, PAIN, doi: 10.1016/j.pain.2013.07.035.
- Masaki Ueno,Yuki Fujita, Tatsuhide Tanaka, Yuka Nakamura, Junichi Kikuta, Masaru Ishii & Toshihide Yamashita. (2013). Layer V cortical neurons require microglial support for survival during postnatal development. Nature Neuroscience 16, 543–551 (2013) doi: 10.1038/nn.3358.
- Sachin Moonat, Amul J. Sakharkar, Huaibo Zhang, Lei Tanga, Subhash C. Pandey. (2013). Aberrant Histone Deacetylase2–Mediated Histone Modifications and Synaptic Plasticity in the Amygdala Predisposes to Anxiety and Alcoholism. Biological Psychiatry, doi: 10.1016/j.biopsych.2013.01.012
- Tsantoulas C, Zhu L, Shaifta Y, Grist J, Ward JP, Raouf R, Michael GJ, McMahon SB. (2012). Sensory neuron downregulation of the Kv9.1 potassium channel subunit mediates neuropathic pain following nerve injury. J Neurosci, 32(48):17502-13. doi: 10.1523/JNEUROSCI.3561-12.2012.
- Masaki Ueno, Yasufumi Hayano1, Hiroshi Nakagawa and Toshihide Yamashita. (2012). Intraspinal rewiring of the corticospinal tract requires target-derived brain-derived neurotrophic factor and compensates lost function after brain injury. Brain, doi: 10.1093/brain/aws053.
- Jing Chen, Xiaolu Zhang, Handojo Kusumo, Lucio G. Costa, c, Marina Guizzettia. (2013). Cholesterol efflux is differentially regulated in neurons and astrocytes: Implications for brain cholesterol homeostasis. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1831 (2), p.263-275, doi: 10.1016/j.bbalip.2012.09.007
- Sylvie Diochot, Anne Baron, Miguel Salinas, Dominique Douguet, Sabine Scarzello, Anne-Sophie Dabert-Gay, Delphine Debayle, Valérie Friend, Abdelkrim Alloui, Michel Lazdunski, Eric Lingueglia. (2012). Black mamba venom peptides target acid-sensing ion channels to abolish pain. Nature, doi:10.1038/nature11494.
- Jacobs VL, Liu Y, De Leo JA. (2012). Propentofylline Targets TROY, a Novel Microglial Signaling Pathway. PLoS ONE, 7(5): e37955. doi: 10.1371/journal.pone.0037955.
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siRNA-mediated suppression of target gene expression in Schwann cells. More information in downloads "Figure Description"
siRNA-mediated suppression of target gene expression in Schwann cells. More information in downloads "Figure Description"