Product Details
Catalog Number: MO25011
Applications: ICC, WB, IHC, IF
Type: Mouse IgG
Immunogen: Bovine RPE microsomal membrane proteins.
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Protein G Purified
Format B: Ascites Fluid
Species Reactivity: Human, Mouse, Bovine
Entrez: 6121
UniProt: Q16518
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
200 ul$390.00Add to Cart

Highly conserved among vertebrate species, RPE65 is a major protein of the retinal pigment epithelium (RPE). RPE65 is essential for the regeneration of rhodopsin in the visual cycle. Mutations in RPE65 are responsible for certain forms of autosomal recessive severe retinal dystrophy, including Leber Congenital Amaurosis (LCA). Loss of function results in a block in retinoid processing required for the synthesis of 11-cis retinal and the accumulation of retinyl esters in the RPE. 

Images
RPE65 staining of mouse retina tissue.

RPE65 staining of mouse retina tissue.

RPE65 staining of mouse retina tissue.

RPE65 staining of mouse retina tissue.

RPE65 detected in bovine and human samples. Lane 1: bovine RPE membrane, lane 2: recombinant human RPE transfected COS7 cell lysate.

RPE65 detected in bovine and human samples. Lane 1: bovine RPE membrane, lane 2: recombinant human RPE transfected COS7 cell lysate.

Questions?
We can help.

We are building our company one satisfied customer at a time. If you have any questions or concerns, please contact us.

Neuromics
5325 West 74th St., Suite 8
Edina, MN 55439

Toll free: 866-350-1500
Int’l phone: 952-374-6161
Fax: 612-677-3976