Trolox

Trolox is a water soluble derivative of vitamin E with potent antioxidant and radical scavenging activities (1). In Hep G2 cells, it stops lipid peroxidation induced by CYP2E1 (2). Trolox also inhibits peroxynitrite-mediated oxidative stress and apoptosis in rat thymocytes (3). It decreases the amount of impaired proliferation of oxidatively stressed myoblasts overexpressing parkin interacting substrate (PARIS/ZNF746) (4). It has been used to compare the antioxidant capacity of other compounds (5) and reference standard for determination of “trolox equivalents” (6).

References:

1) KD Massey et al. Free Radic. Biol. Med.  1990 8:449

2) Q Chen et al. Mol. Pharmacol.  1998 53:638

3) MG Salgo and WA Pryor Arch. Biochem. Biophys. 1996 333:482

4) J-H Bae et al. Cell Death Dis. 2020 11:359

5) H Muñoz et al. Arch. Med. Sci. 2020 16:871

6) R Re et al. Free Radic. Biol. Med. 1999 26:1231