Rufinamide

Rufinamide is an anticonvulsant medication with clinical applications (1). It inhibits Nav1.1 and Nav1.6 activation (2). In gerbils, Rufinamide improved cognitive function and increased neurogenesis by increasing IGF-1, IGF-1R, and p-CREB (3).

References:

1) Hakimian et al. (2007), Rufinamide: a new anti-epileptic medication; Expert Opin.Pharmacother. 8 1931

2) Gilchrist et al. (2014), Nav1.1 Modulation by a Novel Triazole Compound Attenuates Epileptic Seizures in Rodents; ACS Chem.Biol. 9 1204

3) Chen et al. (2018), Rufinamide, an antiepileptic drug, improves cognition and increases neurogenesis in the aged gerbil hippocampal dentate gyrus via increasing expressions of IGF-1, IGF-1R and p-CREB; Chem.Biol.Interact 286 71