Auraptene

Auraptene is a bioactive terpenoid found in many citrus fruits that has been noted as a potential therapeutic (1). It has been shown to display neuritogenic activity (2) and neuroprotective effects through a suppression of inflammation and induction of GDNF and BDNF in neurons (3). Auraptene also inhibits ROS production and boosts mitochondrial respiration which decreases Parkinson’s disease-like symptoms (4). Lastly, it has also been known for hepatoprotective (5) and chemo preventive activity (6).

References:

1) Bibak et al. (2019), A Review of the Pharmacological and Therapeutic Effects of Auraptene; Biofactors, 45 867

2) Furukawa et al. (2012), Neurotrophic Effects of Citrus Auraptene: Neuritogenic Activity in PC12 Cells; Int. J. Mol. Sci., 13 5338

3) Furukawa et al. (2020), Citrus Auraptene Induces Expression of Brain-Derived Neurotrophic Factor in Neuro2a Cells; Molecules, 25 1117

4) Jang et al. (2019), Auraptene Mitigates Parkinson’s Disease-Like Behavior by Protecting Inhibition of Mitochondrial Respiration and Scavenging Reactive Oxygen Species; Int. J. Mol. Sci., 20 3409