Human iPSC - Cortical GABAergic Neurons

Human iPSC- Cortical GABAergic Neurons are derived from integration-free induced pluripotent stem cell (iPSC) lines. Cells are provided at passage 1. 

The nervous system relies on two fundamental interactions between neurons: excitation and inhibition. These processes are mediated by the neurotransmitters glutamate and γ-aminobutyric acid (GABA) for excitatory and inhibitory signals. Dysfunctions in GABAergic neuron activity have been implicated in various neurodevelopmental and neurodegenerative disorders. 

Following our protocol, the GABAergic neurons demonstrate high neuronal purity, with over 90% Tuj1 positive cells, and express the characteristic GABA marker associated with multiple neurodevelopmental and neurodegenerative disorders.