Product Details
Product Sizes
| Size | List Price | Price | Cart |
|---|---|---|---|
| 500,000+ Cells Frozen | $995.00 | $845.75 | Add to Cart |
HRMECs were initiated by elutriation from dissociated normal human retinal tissue. Passage 1 cells are shipped frozen. ENDO-Growth medium is recommended for culture. Cells have an average additional population doubling levels >15 when cultured. Characterization of the cells
HRMECs are negative for HIV-1, HBV, HCV, and mycoplasma. Cells are prepared and manufactured in an ISO 9001:2015 certified environment and ISO 5 cleanroom. |
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- Product Publications
Product Publications
- Jiawei Wang, Nannan Yang, Wanna Li, Han Zhang, and Jianqiao Li. (2024). Role of Hsa_circ_0000880 in the Regulation of High Glucose-Induced Apoptosis of Retinal Microvascular Endothelial Cells. Translational Vision Science & Technology, 13:12. doi: 10.1167/tvst.13.4.12
- Sergio Crespo-Garcia, Frédérik Fournier, Roberto Diaz-Marin, Sharon Klier, Derek Ragusa, Lauren Masaki, Gael Cagnone, Guillaume Blot, Ikhlas Hafiane, Agnieszka Dejda, Rana Rizk, Rachel Juneau, Manuel Buscarlet, Sarah Chorfi, Priyanka Patel, Pedro J. Beltran, Jean-Sebastien Joyal, Flavio A. Rezende, Masayuki Hata, Alex Nguyen, Lynne Sullivan, Jason Damiano, Ariel M. Wilson, Frédérick A. Mallette, Nathaniel E. David, Anirvan Ghosh, Pamela R. Tsuruda, Jamie Dananberg, and Przemyslaw Sapieha. (2024). Therapeutic Targeting of Cellular Senescence in Diabetic Macular Edema: Preclinical and Phase 1 Trial Results. Nature Medicine. doi: 10.1038/s41591-024-02802-4
- Yong Yao Xu, Michael Twarog, Ning Li, Angela Banks, Josh Schustak, Yi Bao, Qian Huang, and Quintus Medley. (2022). Zinc Transport from the Endoplasmic Reticulum to the Cytoplasm via Zip7 is Necessary for Barrier Dysfunction Mediated by Inflammatory Signaling in RPE Cells. PLoS ONE 17(7): e0271656. doi: 10.1371/journal.pone.0271656
- A. Gericke, K. Suminska-Jasinska, and A. Breborowicz. (2021). Sulodexide Reduces Glucose Induced Senescence in Human Retinal Endothelial Cells. Scientific Reports, 11:11532. doi: 10.1038/s41598-021-90987-w
- Fei Cai, Huanzong Jiang, Yan Li, Qin Li, and Chao Yang. (2021). Up-Regulation of Long Non-Coding RNA SNHG16 Promotes Diabetes-Related Retinal Microvascular Endothelial Cell Dysfunction via Activating NF-κB and PI3K/AKT Pathways. Molecular Therapy: Nucleic Acid. doi: 10.1016/j.omtn.2021.01.035
- A. P. Da Cunha, Q. Zhang, M. Prentiss, X. Q. Wu, V. Kainz, Y. Y. Xu, J. Vrouvlianis, H. Li, N. Rangaswamy, B. Leehy, T. L. McGee, C. L. Bell, C. E. Bigelow, V. Kansara, Q. Medley, Q. Huang & H. Y. Wu. The Hierarchy of Proinflammatory Cytokines in Ocular Inflammation. Current Eye Research, Volume 43, 2018 - Issue 4 Published Online: 04 Dec 2017
- Odunayo O. Mugisho, Colin R. Green, Jie Zhang, Nicolette Binz, Monica L. Acosta, Elizabeth Rakoczy and Ilva D. Rupentha. (2017). Immunohistochemical Characterization of Connexin43 Expression in a Mouse Model of Diabetic Retinopathy and in Human Donor Retinas. Int. J. Mol. Sci. doi: 10.3390/ijms18122567
- Michael Anthony Ruiz, Biao Feng, and Subrata Chakrabarti. (2015). Polycomb Repressive Complex 2 Regulates MiR-200b in Retinal Endothelial Cells: Potential Relevance in Diabetic Retinopathy. PLoS One.10(4): e0123987. doi: 10.1371/journal.pone.0123987.
Product Patent Application
- Pam Tsuruda, Jill Hopkins, Harry Sweigard, Yan Poon, Jamie Dananberg, Daniel Marquess, and Nathaniel David. (2020). Methods of Inhibiting Pathological Angiogenesis. United States Patent Application 20200253991
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Images
Effect of HG (high glucose) and pro-inflammatory cytokines on connexin43 expression in HRMECs. Immunohistochemical data showing connexin43 expression in (A) normal medium; (B) HG (25 mM); (C) pro-inflammatory cytokines (IL-1β and TNF-α 10 ng/mL each); and (D) a combination of HG and pro-inflammatory cytokines inducing a change in cell morphology with signs of cell swelling, possibly owing to hemichannel opening (indicated by white arrows). https://doi.org/10.1080/02713683.2017.1410180
Effect of HG (high glucose) and pro-inflammatory cytokines on connexin43 expression in HRMECs. Immunohistochemical data showing connexin43 expression in (A) normal medium; (B) HG (25 mM); (C) pro-inflammatory cytokines (IL-1β and TNF-α 10 ng/mL each); and (D) a combination of HG and pro-inflammatory cytokines inducing a change in cell morphology with signs of cell swelling, possibly owing to hemichannel opening (indicated by white arrows). https://doi.org/10.1080/02713683.2017.1410180
Retinal Microvascular Endothelial Cells in culture
Retinal Microvascular Endothelial Cells in culture