Product Details
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| Size | List Price | Price | Cart |
|---|---|---|---|
| 100 ug | $365.00 | Add to Cart |
Neurogranin is a calmodulin-binding protein expressed exclusively in the brain, particularly in dendritic spines, and participating in the protein kinase C signaling pathway. Neurogranin is the main postsynaptic protein regulating the availability of calmodulin, binding to it in the absence of calcium. Phosphorylation by protein kinase C lowers its binding ability Neurogranin is downregulate in Schizophrenia and is not found in the dendrites in patients with Alzheimer disease. |
Images
Neurogranin precursor (dilution: 0.1µg/ml) staining of Mouse Brain lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Neurogranin (dilution: 4.0 µg/ml) staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Protocol on data-sheet.