FOXN1

FOX1N or Forkhead box N1 is involved in T-cell development. Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system.

Defects in FOXN1 are the cause of T-cell immunodeficiency congenital alopecia and nail dystrophy. A disorder characterized by the association of congenital alopecia, severe T-cell immunodeficiency, and ridging and pitting of all nails.