Product Details
Product Sizes
| Size | List Price | Price | Cart |
|---|---|---|---|
| 100 ul | $329.00 | Add to Cart |
Myristolyated alanine rich C-kinase substrate, hence MARCKS, was originally discovered by as a major substrate for protein kinase C in the brain and other tissues. MARCKS interacts with actin and calcium in a manner regulated by protein kinase C. It is a major protein of the brain concentrated in the synapses of neurons and is membrane localized due to the N-terminal lipid myristoyl group. Antibody to MARCKS can therefore be used as a marker of synaptic regions. Genetic knock out of MARCKS in transgenic mice is perinatal lethal and associated with aberrant brain development suggesting a fundamental importance in the CNS. This antibody was made against recombinant full length human MARCKS expressed in and purified from E. coli. The antibody works well on human cells and tissues but is not recommended for work on rodent material. Product Highlights: |
- Product Reviews- - Rating:
Leave a review for this product and you could be eligible for a $10 Starbucks gift card.
- Product Publications
Product Publications
If you've used this product in a publication, let us know. Email pshuster@neuromics.com, with the publication details and you could be eligible for an Amazon gift card.
- Related Products
Related Products
Name Catalog # Size Bradykinin Receptor B2 RA14137 100 ul CADM1/SynCAM RA25084 100 ul Calbindin CH22118 100 ul Calbindin MO20016 100 ug Calreticulin MO22164 100 ul Calretinin CH22116 100 ul Calretinin MO20024 100 ul Calretinin MO22166 100 ul Calretinin RA22144 100 ul Calretinin (IgG1) MO22165 100 ul CaMKII2A GT41019 100 ug MARCKS (Myristoylated Alanine Rich C Kinase Substrate) RA22111 100 ul Neurogranin precursor GT41024 100 ug phospho-Synapsin (Ser9) RA18009 100 ul S-100 MO47059 100 ul SHANK1a N-Terminus RA19015 100 ug Striatin RA25067 100 ul Synapsin RA18010 100 ul
Images
Immunofluorescent analysis of HeLa cells stained with chicken pAb to MARCKS, CH22137, dilution 1:5,000 in red, and costained with mouse mAb to β-tubulin in green. The blue is Hoechst staining of nuclear DNA. The MARCKS antibody binds to MARCKS protein expressed in the plasma membrane and cytoplasm, while the β-tubulin antibody stains cytoplasmic microtubules.
Immunofluorescent analysis of HeLa cells stained with chicken pAb to MARCKS, CH22137, dilution 1:5,000 in red, and costained with mouse mAb to β-tubulin in green. The blue is Hoechst staining of nuclear DNA. The MARCKS antibody binds to MARCKS protein expressed in the plasma membrane and cytoplasm, while the β-tubulin antibody stains cytoplasmic microtubules.
Western blot analysis of different cell lines lysates using chicken pAB to MARCKS, CH22137, dilution 1:1,000 in green: [1] protein standard (red), [2] HEK293, [3] HeLa, [4] SH-SY5Y, and [5] COS1 cells. Strong band at 80kDa corresponds to MARCKS protein. The same blot was simultaneously probed with mouse mAb to GAPDH in red, which reveals a single band at 37kDa in all preparations.
Western blot analysis of different cell lines lysates using chicken pAB to MARCKS, CH22137, dilution 1:1,000 in green: [1] protein standard (red), [2] HEK293, [3] HeLa, [4] SH-SY5Y, and [5] COS1 cells. Strong band at 80kDa corresponds to MARCKS protein. The same blot was simultaneously probed with mouse mAb to GAPDH in red, which reveals a single band at 37kDa in all preparations.