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Currently out of stock - contact david@neuromics.com for more information - Replacement antibody RA14142 Met-enkephalin (tyr-gly-gly-phe-met) and leu-enkephalin (tyr-gly-gly-phe-leu) are pentapeptides which compete with and mimic the effects of opiate drugs. Although interest in enkephalins stems largely from their possible role in the brain, the richest source of these peptides is the adrenal gland. The amino acid sequence shows that the precursor is 267 amino acids long and contains 6 interspersed Met-enkephalin sequences and 1 Leu-enkephalin sequence. The precursor does not contain the sequences of dynorphin, alpha-neo-endorphin or beta-endorphin. (Because of structural similarities it had been postulated that beta-endorphin is precursor of Met-enkephalin, and that dynorphin or alpha-neo-endorphin is precursor of Leu-enkephalin.) It is involved in the modulation of nociceptive pain. ppENK may be capable of enhancing immune function in cancer or AIDS patients. |
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- Kelsey Vollmer, Lisa Green, Roger Grant, Kion Winston, Elizabeth Doncheck, Christopher Bowen, Jacqueline Paniccia, Rachel Clarke, Annika Tiller, Preston Siegler, Benjamin Siemsen, Adam Denton, Thomas Jhou, Jennifer Rinker, Michael Scoeld, and James Otis. (2022). A Thalamostriatal Parvalbumin Interneuron Circuit Suppresses Risky Reward-Motivated Behaviors and Is Disengaged by Opioids. doi: 10.21203/rs.3.rs-1527325/v1
- Christina Grimm, Stefan Frässle, Céline Steger, Lukasvon Ziegler, Oliver Sturman, Noam Shemesh, Daria Peleg-Raibstein, Denis Burdakov, Johannes Bohacek, Klaas Enno Stephan, Daniel Razansky, Nicole Wenderoth, and Valerio Zerbi. (2021). Optogenetic Activation of Striatal D1R and D2R Cells Differentially Engages Downstream Connected Areas Beyond the Basal Ganglia. Cell Reports, 37(11): 110161. doi: 10.1016/j.celrep.2021.110161
- Koki Nagaoka, Takuya Nagashima, Nozomi Asaoka, Hiroki Yamamoto, Chihiro Toda, Gen Kayanuma, Soni Siswanto, Yasuhiro Funahashi, Keisuke Kuroda, Kozo Kaibuchi, Yasuo Mori, Kazuki Nagayasu, Hisashi Shirakawa, and Shuji Kaneko. (2021). Striatal TRPV1 Activation by Acetaminophen Ameliorates Dopamine D2 Receptor 4 Antagonists-Induced Orofacial Dyskinesia. JCI Insight. doi: 10.1172/jci.insight.145632
- Anastasia Brodovskaya, Shinnosuke Shiono, and Jaideep Kapur. (2021). Activation of the Basal Ganglia and Indirect Pathway Neurons During Frontal Lobe Seizures. Brain. doi: 10.1093/brain/awab119
- Craig M. Smith, Joshua Cross, Izel M. Eraslan, Aparna Attawar, Sarah Ch’ng, Poshmaal Dhar, Rasika Samarasinghe, Laura Gray, and Andrew J. Lawrence. (2019). Phenotyping Neurons Activated in the Mouse Brain During Restoration of Salt Debt. Journal of Chemical Neuroanatomy. doi: 10.1016/j.jchemneu.2019.101665
- Nicolas Merienne, Cécile Meunier, Anne Schneider, Jonathan Seguin, Satish S.Nair, Anne B. Rocher, Stéphanie Le Gras, Céline Keime, Richard Faull, Luc Pellerin, Jean-Yves Chatton, Christian Neri, Karine Merienne, Nicole Déglon (2019). Cell-Type-Specific Gene Expression Profiling in Adult Mouse Brain Reveals Normal and Disease-State Signatures. Cell Reports. Volume 26, Issue 9, 26 February 2019, Pages 2477-https://doi.org/10.1016/j.celrep.2019.02.003
- Magdalena Sikora, Krzysztof Tokarski, Bartosz Bobula, Joanna Zajdel, Kamila Jastrzebska, Przemyslaw Eligiusz Cieslak, Magdalena Zygmunt, Joanna Sowa, Magdalena Smutek, Katarzyna Kaminska, Krystyna Golembiowska, David Engblom, Grzegorz Hess, Ryszard Przewlocki and Jan Rodriguez Parkitna. (2016). NMDA receptors on dopaminoceptive neurons are essential for drug-induced conditioned place preference. eNeuro, doi: 10.1523/ENEURO.0084-15.2016
- Alessandra Bonito-Oliva, Erik Södersten, Giada Spigolon, Xiaochen Hu, Arash Hellysaz, Anastasia Falconi, Ana-Luisa Gomes, Christian Broberger, Dr. Klaus Hansen, and Dr. Gilberto Fisone. (2015). Differential Regulation of the Phosphorylation of Trimethyl-lysine27 Histone H3 at Serine 28 in Distinct Populations of Striatal Projection Neurons. Neuropharmacology, doi: 10.1016/j.neuropharm.2016.02.037
- Teri M. Furlong, Hirosha K. Jayaweera, Bernard W. Balleine, and Laura H. Corbit. (2014). Binge-Like Consumption of a Palatable Food Accelerates Habitual Control of Behavior and Is Dependent on Activation of the Dorsolateral Striatum. The Journal of Neuroscience, 34(14): 5012-5022; doi: 10.1523/JNEUROSCI.3707-13.2014
- Sabrina L. Ena, Jean-François De Backer, Serge N. Schiffmann, and Alban de Kerchove d'Exaerde. (2013). FACS Array Profiling Identifies Ecto-5′ Nucleotidase as a Striatopallidal Neuron-Specific Gene Involved in Striatal-Dependent Learning. The Journal of Neuroscience, 33(20):8794-8809; doi: 10.1523/JNEUROSCI.2989-12.2013
- Martin Novak, Briac Halbout, Eoin C. O'Connor, Jan Rodriguez Parkitna, Tian, Su, Minqiang Chai, Hans S. Crombag, Ainhoa Bilbao, Rainer Spanagel, David N. Stephens, Günther Schütz, and David Engblom. (2010). Incentive Learning Underlying Cocaine-Seeking Requires mGluR5 Receptors Located on Dopamine D1 Receptor-Expressing Neurons. J. Neurosci., 30: 11973 - 11982. doi: 10.1523/JNEUROSCI.2550-10.2010
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Mouse striatum stained with D2 cell marker Enkephalin (RA14124) in green and with neuronal marker NeuN in red courtesy of Dr Heike Rebholz of City College of New York.
Mouse striatum stained with D2 cell marker Enkephalin (RA14124) in green and with neuronal marker NeuN in red courtesy of Dr Heike Rebholz of City College of New York.
Expression of ppENK in mouse striatal medium spiny neurons (MSNs). The Journal of Neuroscience, 8 September 2010, 30(36): 11973-11982;doi: 10.1523/JNEUROSCI.2550-10.2010.
Expression of ppENK in mouse striatal medium spiny neurons (MSNs). The Journal of Neuroscience, 8 September 2010, 30(36): 11973-11982;doi: 10.1523/JNEUROSCI.2550-10.2010.